Catalytically active species for CeCi3-induced DNA hydrolysis

Makoto Komiyama, Teruyuki Kodama, Naoya Takeda, Jun Sumaoka, Tetsuro Shiiba, Yoichi Matsumoto, Morio Yashiro

Research output: Contribution to journalArticle

38 Citations (Scopus)


Cerium(III) chloride efficiently hydrolyzes DNA at pH 7 under aerobic conditions. A titration study showed that Ce(III) is oxidized to Ce(IV) in the reaction mixture and the resultant Ce(IV) is responsible for the DNA hydrolysis.

Original languageEnglish
Pages (from-to)809-810
Number of pages2
JournalJournal of Biochemistry
Issue number5
Publication statusPublished - 1994 May
Externally publishedYes



  • Artificial restriction enzyme
  • Ce(IV) ion
  • Cerium(III) chloride
  • DNA hydrolysis

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Molecular Biology
  • Biochemistry

Cite this

Komiyama, M., Kodama, T., Takeda, N., Sumaoka, J., Shiiba, T., Matsumoto, Y., & Yashiro, M. (1994). Catalytically active species for CeCi3-induced DNA hydrolysis. Journal of Biochemistry, 115(5), 809-810.