Cdk5/p35 functions as a crucial regulator of spatial learning and memory

Tomohide Mishiba, Mika Tanaka, Naoki Mita, Xiaojuan He, Kodai Sasamoto, Shigeyoshi Itohara, Toshio Ohshima

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    BACKGROUND: Cyclin-dependent kinase 5 (Cdk5), which is activated by binding to p35 or p39, is involved in synaptic plasticity and affects learning and memory formation. In Cdk5 knockout (KO) mice and p35 KO mice, brain development is severely impaired because neuronal migration is impaired and lamination is disrupted. To avoid these developmental confounders, we generated inducible CreER-p35 conditional (cKO) mice to study the role of Cdk5/p35 in higher brain function.

    RESULTS: CreER-p35 cKO mice exhibited spatial learning and memory impairments and reduced anxiety-like behavior. These phenotypes resulted from a decrease in the dendritic spine density of CA1 pyramidal neurons and defective long-term depression induction in the hippocampus.

    CONCLUSIONS: Taken together, our findings reveal that Cdk5/p35 regulates spatial learning and memory, implicating Cdk5/p35 as a therapeutic target in neurological disorders.

    Original languageEnglish
    Pages (from-to)82
    Number of pages1
    JournalMolecular Brain
    Volume7
    DOIs
    Publication statusPublished - 2014

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    Cyclin-Dependent Kinase 5
    Knockout Mice
    Dendritic Spines
    Neuronal Plasticity
    Pyramidal Cells
    Brain
    Nervous System Diseases
    Hippocampus
    Anxiety
    Spatial Memory
    Spatial Learning
    Learning
    Depression
    Phenotype

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Cdk5/p35 functions as a crucial regulator of spatial learning and memory. / Mishiba, Tomohide; Tanaka, Mika; Mita, Naoki; He, Xiaojuan; Sasamoto, Kodai; Itohara, Shigeyoshi; Ohshima, Toshio.

    In: Molecular Brain, Vol. 7, 2014, p. 82.

    Research output: Contribution to journalArticle

    Mishiba, Tomohide ; Tanaka, Mika ; Mita, Naoki ; He, Xiaojuan ; Sasamoto, Kodai ; Itohara, Shigeyoshi ; Ohshima, Toshio. / Cdk5/p35 functions as a crucial regulator of spatial learning and memory. In: Molecular Brain. 2014 ; Vol. 7. pp. 82.
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    AU - Mishiba, Tomohide

    AU - Tanaka, Mika

    AU - Mita, Naoki

    AU - He, Xiaojuan

    AU - Sasamoto, Kodai

    AU - Itohara, Shigeyoshi

    AU - Ohshima, Toshio

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