Cdk5/p35 regulates neuronal migration

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Neurons migrate from proliferative zone to their final position during brain development. Cyclin-dependent kinase 5 (Cdk5) plays an important role in neuronal migration to establish a proper structure of the brain. Analyses of Cdk5/p35-deficient mice have provided the knowledge about the role of Cdk5/p35 in neuronal migration. Over the past years, migration-related substrates of Cdk5 have been identified. Imaging analyses of neuronal migration of Cdk5/p35-deficient neurons have begun to elucidate how proper phosphorylations of these proteins by Cdk5/p35 are required for the regulation of cytoskeletal dynamics and cellular adhesion during neuronal migration.

    Original languageEnglish
    Title of host publicationCyclin Dependent Kinase 5 (Cdk5)
    PublisherSpringer US
    Pages1-8
    Number of pages8
    ISBN (Print)9780387788876, 9780387788869
    DOIs
    Publication statusPublished - 2008

    Fingerprint

    Cyclin-Dependent Kinase 5
    Neurons
    Brain
    Phosphorylation

    ASJC Scopus subject areas

    • Medicine(all)
    • Neuroscience(all)

    Cite this

    Ohshima, T. (2008). Cdk5/p35 regulates neuronal migration. In Cyclin Dependent Kinase 5 (Cdk5) (pp. 1-8). Springer US. https://doi.org/10.1007/978-0-387-78887-6_1

    Cdk5/p35 regulates neuronal migration. / Ohshima, Toshio.

    Cyclin Dependent Kinase 5 (Cdk5). Springer US, 2008. p. 1-8.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Ohshima, T 2008, Cdk5/p35 regulates neuronal migration. in Cyclin Dependent Kinase 5 (Cdk5). Springer US, pp. 1-8. https://doi.org/10.1007/978-0-387-78887-6_1
    Ohshima T. Cdk5/p35 regulates neuronal migration. In Cyclin Dependent Kinase 5 (Cdk5). Springer US. 2008. p. 1-8 https://doi.org/10.1007/978-0-387-78887-6_1
    Ohshima, Toshio. / Cdk5/p35 regulates neuronal migration. Cyclin Dependent Kinase 5 (Cdk5). Springer US, 2008. pp. 1-8
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