Cell adhesion control by photoinduced LCST shift of PNIPAAm-based brush scaffolds

Keiichi Imato, Kazuho Nagata, Rina Watanabe, Naoya Takeda

Research output: Contribution to journalArticle

Abstract

Poly(N-isopropylacrylamide) (PNIPAAm)-brush substrates are one of the most successful dynamic scaffolds for thermally controlling cell adhesion. Endowing substrates with photocontrollability promises further development and applications in the biomedical and bioengineering fields. In this study, we developed photoresponsive PNIPAAm copolymers by incorporation of spiropyran into the polymer chain, enabling the photoinduced shift of the lower critical solution temperatures. Their brush substrates were fabricated in a simple, facile grafting-to manner. Co-grafting with non-cell-adhesive poly(ethylene glycol) enhanced the modulation of surface chemical properties upon photostimulation; it enabled significant photocontrol of cell adhesion of several types with keeping culture temperature constant.

Original languageEnglish
Pages (from-to)2393-2399
Number of pages7
JournalJournal of Materials Chemistry B
Volume8
Issue number12
DOIs
Publication statusPublished - 2020 Mar 28

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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