Cell competition in mammals — novel homeostatic machinery for embryonic development and cancer prevention

Takeshi Maruyama, Yasuyuki Fujita

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

In the multi-cellular community, cells with different properties often compete with each other for survival and space. This process is named cell competition and was originally discovered in Drosophila. Recent studies have revealed that comparable phenomena also occur in mammals under various physiological and pathological conditions. Within the epithelium, normal cells often recognize the presence of the neighboring transformed cells and actively eliminate them from the epithelium; a process termed EDAC (Epithelial Defense Against Cancer). Furthermore, physical force can play a crucial role in the intercellular recognition and elimination of loser cells during cell competition. Further studies are expected to reveal a variety of roles of cell competition in embryonic development and human diseases.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume48
DOIs
Publication statusPublished - 2017 Oct

ASJC Scopus subject areas

  • Cell Biology

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