Cell delivery using micropatterned ultra-thin polymeric films

Yoshihiro Mori, Toshinori Fujie, Nobuhiro Nagai, Matsuhiko Nishizawa, Ali Khademhosseini, Toshiaki Abe, Hirokazu Kaji

Research output: Contribution to journalArticle

Abstract

We developed micropatterned polymeric ultra-thin films (nanosheets) consisting of biodegradable poly(lactic-co-glycolic acid) (PLGA) and magnetic nanoparticles (MNPs), on which monolayer of retinal pigment epithelial (RPE) cells were formed. The viability of RPE cells on the micropatterned nanosheets were evaluated along the syringe manipulation equipped with a clinical needle. Finally, subretinal injectability of the macropatterned nanosheets was demonstrated by using ex vivo swine eyes in terms of handleability and physical stability. The micropatterned nanosheets injectable by clinical syringe hold a great promise to transplant functional RPE cells minimum invasively.

Original languageEnglish
Pages (from-to)O-192-O-193
JournalTransactions of Japanese Society for Medical and Biological Engineering
Volume52
DOIs
Publication statusPublished - 2014 Aug 17

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Keywords

  • Cell delivery
  • Nanosheet
  • PLGA
  • RPE

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Mori, Y., Fujie, T., Nagai, N., Nishizawa, M., Khademhosseini, A., Abe, T., & Kaji, H. (2014). Cell delivery using micropatterned ultra-thin polymeric films. Transactions of Japanese Society for Medical and Biological Engineering, 52, O-192-O-193. https://doi.org/10.11239/jsmbe.52.O-192