Abstract
We developed micropatterned polymeric ultra-thin films (nanosheets) consisting of biodegradable poly(lactic-co-glycolic acid) (PLGA) and magnetic nanoparticles (MNPs), on which monolayer of retinal pigment epithelial (RPE) cells were formed. The viability of RPE cells on the micropatterned nanosheets were evaluated along the syringe manipulation equipped with a clinical needle. Finally, subretinal injectability of the macropatterned nanosheets was demonstrated by using ex vivo swine eyes in terms of handleability and physical stability. The micropatterned nanosheets injectable by clinical syringe hold a great promise to transplant functional RPE cells minimum invasively.
| Original language | English |
|---|---|
| Pages (from-to) | O-192-O-193 |
| Journal | Transactions of Japanese Society for Medical and Biological Engineering |
| Volume | 52 |
| DOIs | |
| Publication status | Published - 2014 Aug 17 |
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Keywords
- Cell delivery
- Nanosheet
- PLGA
- RPE
ASJC Scopus subject areas
- Biomedical Engineering
Cite this
Cell delivery using micropatterned ultra-thin polymeric films. / Mori, Yoshihiro; Fujie, Toshinori; Nagai, Nobuhiro; Nishizawa, Matsuhiko; Khademhosseini, Ali; Abe, Toshiaki; Kaji, Hirokazu.
In: Transactions of Japanese Society for Medical and Biological Engineering, Vol. 52, 17.08.2014, p. O-192-O-193.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cell delivery using micropatterned ultra-thin polymeric films
AU - Mori, Yoshihiro
AU - Fujie, Toshinori
AU - Nagai, Nobuhiro
AU - Nishizawa, Matsuhiko
AU - Khademhosseini, Ali
AU - Abe, Toshiaki
AU - Kaji, Hirokazu
PY - 2014/8/17
Y1 - 2014/8/17
N2 - We developed micropatterned polymeric ultra-thin films (nanosheets) consisting of biodegradable poly(lactic-co-glycolic acid) (PLGA) and magnetic nanoparticles (MNPs), on which monolayer of retinal pigment epithelial (RPE) cells were formed. The viability of RPE cells on the micropatterned nanosheets were evaluated along the syringe manipulation equipped with a clinical needle. Finally, subretinal injectability of the macropatterned nanosheets was demonstrated by using ex vivo swine eyes in terms of handleability and physical stability. The micropatterned nanosheets injectable by clinical syringe hold a great promise to transplant functional RPE cells minimum invasively.
AB - We developed micropatterned polymeric ultra-thin films (nanosheets) consisting of biodegradable poly(lactic-co-glycolic acid) (PLGA) and magnetic nanoparticles (MNPs), on which monolayer of retinal pigment epithelial (RPE) cells were formed. The viability of RPE cells on the micropatterned nanosheets were evaluated along the syringe manipulation equipped with a clinical needle. Finally, subretinal injectability of the macropatterned nanosheets was demonstrated by using ex vivo swine eyes in terms of handleability and physical stability. The micropatterned nanosheets injectable by clinical syringe hold a great promise to transplant functional RPE cells minimum invasively.
KW - Cell delivery
KW - Nanosheet
KW - PLGA
KW - RPE
UR - http://www.scopus.com/inward/record.url?scp=84939448021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939448021&partnerID=8YFLogxK
U2 - 10.11239/jsmbe.52.O-192
DO - 10.11239/jsmbe.52.O-192
M3 - Article
AN - SCOPUS:84939448021
VL - 52
SP - O-192-O-193
JO - BME = Bio medical engineering / henshu, Nihon ME Gakkai
JF - BME = Bio medical engineering / henshu, Nihon ME Gakkai
SN - 1347-443X
ER -