Cell Mechanosensors and the Possibilities of Using Magnetic Nanoparticles to Study Them and to Modify Cell Fate

Yajing Shen, Yu Cheng, Taro Q.P. Uyeda, Gustavo R. Plaza

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The use of magnetic nanoparticles (MNPs) is a promising technique for future advances in biomedical applications. This idea is supported by the availability of MNPs that can target specific cell components, the variety of shapes of MNPs and the possibility of finely controlling the applied magnetic forces. To examine this opportunity, here we review the current developments in the use of MNPs to mechanically stimulate cells and, specifically, the cell mechanotransduction systems. We analyze the cell components that may act as mechanosensors and their effect on cell fate and we focus on the promising possibilities of controlling stem-cell differentiation, inducing cancer-cell death and treating nervous-system diseases.

Original languageEnglish
Pages (from-to)2475-2486
Number of pages12
JournalAnnals of Biomedical Engineering
Volume45
Issue number10
DOIs
Publication statusPublished - 2017 Oct 1

Keywords

  • Cell differentiation
  • Cytoskeleton
  • Functionalization
  • Localized stimulation
  • Magnetic nanoparticles
  • Mechanotransduction
  • Organelle targeting
  • Rotating magnetic field
  • Signaling cascade

ASJC Scopus subject areas

  • Biomedical Engineering

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