Cell signaling: IP3 receptor types 2 and 3 mediates exocrine secretion underlying energy metabolism

Akira Futatsugi, Takeshi Nakamura, Maki K. Yamada, Etsuko Ebisui, Kyoko Nakamura, Kelko Uchida, Tetsuya Kitaguchi, Hiromi Takashi-Iwanaga, Tetsuo Noda, Jun Aruga, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

220 Citations (Scopus)

Abstract

Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP3R2 and IP3RB) are intracellular calcium-release channels whose physiological roles are unknown. We show exocrine dysfunction in IP 3R2 and IP3R3 double knock-out mice, which caused difficulties in nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands and the pancreas in the double mutants ascribed the secretion deficits to a lack of intracellular calcium release. Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP3R2 and IP3R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth.

Original languageEnglish
Pages (from-to)2232-2234
Number of pages3
JournalScience
Volume309
Issue number5744
DOIs
Publication statusPublished - 2005 Sep 30
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Futatsugi, A., Nakamura, T., Yamada, M. K., Ebisui, E., Nakamura, K., Uchida, K., Kitaguchi, T., Takashi-Iwanaga, H., Noda, T., Aruga, J., & Mikoshiba, K. (2005). Cell signaling: IP3 receptor types 2 and 3 mediates exocrine secretion underlying energy metabolism. Science, 309(5744), 2232-2234. https://doi.org/10.1126/science.1114110