Central circulatory and peripheral O2 extraction changes as interactive facilitators of pulmonary O2 uptake during a repeated high-intensity exercise protocol in humans

Yoshiyuki Fukuba*, Masako Yamaoka Endo, Yukie Ohe, Yuiko Hirotoshi, Asami Kitano, Chiaki Shiragiku, Akira Miura, Osamu Fukuda, Hatsumi Ueoka, Motohiko Miyachi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


It has frequently been demonstrated that prior high-intensity exercise facilitates pulmonary oxygen uptake (V̇O2) response at the onset of subsequent identical exercise. To clarify the roles of central O2 delivery and/or peripheral O2 extraction in determining this phenomenon, we investigated the relative contributions of cardiac output (CO) and arteriovenous O2 content difference (a-v̄DO2) to the V̇O2) transient during repeated bouts of high-intensity knee extension (KE) exercise. Nine healthy subjects volunteered to participate in this study. The protocol consisted of two consecutive 6-min KE exercise bouts in a supine position (work rate 70-75% of peak power) separated by 6 min of rest. Throughout the protocol, continuous-wave Doppler ultrasound was used to measure beat-by-beat CO (i.e., via simultaneous measurement of stroke volume and the diameter of the arterial aorta). The phase II V̇O2 response was significantly faster and the slow component (phase III) was significantly attenuated during the second KE bout compared to the first. This was a result of increased CO during the first 30 s of exercise: CO contributing to 100 and 56% of the V̇O2 speeding at 10 and 30 s, respectively. After this, the contribution of a-v̄DO2 to the V̇O2 became increasingly more predominant: being responsible to an estimated 64% of the V̇O2 speeding at 90 s, which rose to 100% by 180 s. This suggests that, while both CO and a-v̄DO2 clearly interact to determine the V̇O2 response, the speeding of V̇O2 kinetics by prior high-intensity KE exercise is predominantly attributable to increases in a-v̄DO2.

Original languageEnglish
Pages (from-to)361-369
Number of pages9
JournalEuropean Journal of Applied Physiology
Issue number4
Publication statusPublished - 2007 Mar
Externally publishedYes


  • Arteriovenous O content difference
  • Cardiac output
  • High-intensity exercise

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)


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