Cerebral blood flow and neurovascular coupling during static exercise

Yuji Yamaguchi, Hideaki Kashima, Yoshiyuki Fukuba, Naoyuki Hayashi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The effect of static exercise on neurovascular coupling (NVC) was investigated by measuring the blood flow velocity in the posterior cerebral artery (PCAv) during 2-min static handgrip exercises (HG) at 30 % of the maximum voluntary contraction in 17 healthy males. NVC was estimated as the relative change in PCAv from eye closing to a peak response to looking at a reversed checkerboard. The conductance index (CI) was calculated by dividing PCAv by the mean arterial pressure (MAP). HG significantly increased PCAv from the resting baseline, with an increase in MAP and a reduction in CI, whereas NVC did not differ significantly between the resting and HG. Compared to the resting baseline, HG significantly increased the pressor response to visual stimulation by 5.6 ± 1.1 (mean ± SE) mmHg, while the CI response was significantly inhibited by -7.0 ± 1.5 %. These results indicate that NVC was maintained during HG via contributions from both the pressor response and vasodilatation.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalJournal of Physiological Sciences
Volume64
Issue number3
DOIs
Publication statusPublished - 2014 May
Externally publishedYes

Keywords

  • Exercise pressor reflex
  • Post-exercise muscle ischaemia
  • Posterior cerebral artery
  • Static handgrip exercise

ASJC Scopus subject areas

  • Physiology

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