Cerebral cortex

Symmetric vs: asymmetric cell division

G. Fishell, Carina Hanashima

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The six distinct laminae within the mammalian cerebral cortex contain neurons that exhibit a wide variety of specific physiological properties and synaptic connections. This diversity emerges from a restricted progenitor pool within the embryonic cortical ventricular zone. Individual cortical progenitors produce multiple subtypes over a prolonged period during corticogenesis. This article describes classical studies that suggest that neurogenesis in the cerebral cortex is dependent on asymmetric divisions, where one daughter remains in a progenitor state while the other exits to become a mature neuron. The present understanding of the molecular mechanisms regulating both asymmetric cell division and the sequential production of different neuronal subtypes during development is reviewed. However, as yet only a subset of the factors controlling each of these two events has been identified. This suggests that present genetic approaches will soon significantly extend our understanding of these developmental processes.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages785-791
Number of pages7
ISBN (Print)9780080450469
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Asymmetric Cell Division
Cerebral Cortex
Neurons
Neurogenesis

Keywords

  • Asymmetric cell division
  • Cell fate specification
  • Cerebral cortex
  • Cortical layer
  • Cortical progenitor
  • Neurogenesis
  • Radial glial cell
  • Subventricular zone
  • Ventricular zone

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fishell, G., & Hanashima, C. (2010). Cerebral cortex: Symmetric vs: asymmetric cell division. In Encyclopedia of Neuroscience (pp. 785-791). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.01029-9

Cerebral cortex : Symmetric vs: asymmetric cell division. / Fishell, G.; Hanashima, Carina.

Encyclopedia of Neuroscience. Elsevier Ltd, 2010. p. 785-791.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fishell, G & Hanashima, C 2010, Cerebral cortex: Symmetric vs: asymmetric cell division. in Encyclopedia of Neuroscience. Elsevier Ltd, pp. 785-791. https://doi.org/10.1016/B978-008045046-9.01029-9
Fishell, G. ; Hanashima, Carina. / Cerebral cortex : Symmetric vs: asymmetric cell division. Encyclopedia of Neuroscience. Elsevier Ltd, 2010. pp. 785-791
@inbook{dba98efa03704860b3f3682b989b2ae2,
title = "Cerebral cortex: Symmetric vs: asymmetric cell division",
abstract = "The six distinct laminae within the mammalian cerebral cortex contain neurons that exhibit a wide variety of specific physiological properties and synaptic connections. This diversity emerges from a restricted progenitor pool within the embryonic cortical ventricular zone. Individual cortical progenitors produce multiple subtypes over a prolonged period during corticogenesis. This article describes classical studies that suggest that neurogenesis in the cerebral cortex is dependent on asymmetric divisions, where one daughter remains in a progenitor state while the other exits to become a mature neuron. The present understanding of the molecular mechanisms regulating both asymmetric cell division and the sequential production of different neuronal subtypes during development is reviewed. However, as yet only a subset of the factors controlling each of these two events has been identified. This suggests that present genetic approaches will soon significantly extend our understanding of these developmental processes.",
keywords = "Asymmetric cell division, Cell fate specification, Cerebral cortex, Cortical layer, Cortical progenitor, Neurogenesis, Radial glial cell, Subventricular zone, Ventricular zone",
author = "G. Fishell and Carina Hanashima",
year = "2010",
doi = "10.1016/B978-008045046-9.01029-9",
language = "English",
isbn = "9780080450469",
pages = "785--791",
booktitle = "Encyclopedia of Neuroscience",
publisher = "Elsevier Ltd",

}

TY - CHAP

T1 - Cerebral cortex

T2 - Symmetric vs: asymmetric cell division

AU - Fishell, G.

AU - Hanashima, Carina

PY - 2010

Y1 - 2010

N2 - The six distinct laminae within the mammalian cerebral cortex contain neurons that exhibit a wide variety of specific physiological properties and synaptic connections. This diversity emerges from a restricted progenitor pool within the embryonic cortical ventricular zone. Individual cortical progenitors produce multiple subtypes over a prolonged period during corticogenesis. This article describes classical studies that suggest that neurogenesis in the cerebral cortex is dependent on asymmetric divisions, where one daughter remains in a progenitor state while the other exits to become a mature neuron. The present understanding of the molecular mechanisms regulating both asymmetric cell division and the sequential production of different neuronal subtypes during development is reviewed. However, as yet only a subset of the factors controlling each of these two events has been identified. This suggests that present genetic approaches will soon significantly extend our understanding of these developmental processes.

AB - The six distinct laminae within the mammalian cerebral cortex contain neurons that exhibit a wide variety of specific physiological properties and synaptic connections. This diversity emerges from a restricted progenitor pool within the embryonic cortical ventricular zone. Individual cortical progenitors produce multiple subtypes over a prolonged period during corticogenesis. This article describes classical studies that suggest that neurogenesis in the cerebral cortex is dependent on asymmetric divisions, where one daughter remains in a progenitor state while the other exits to become a mature neuron. The present understanding of the molecular mechanisms regulating both asymmetric cell division and the sequential production of different neuronal subtypes during development is reviewed. However, as yet only a subset of the factors controlling each of these two events has been identified. This suggests that present genetic approaches will soon significantly extend our understanding of these developmental processes.

KW - Asymmetric cell division

KW - Cell fate specification

KW - Cerebral cortex

KW - Cortical layer

KW - Cortical progenitor

KW - Neurogenesis

KW - Radial glial cell

KW - Subventricular zone

KW - Ventricular zone

UR - http://www.scopus.com/inward/record.url?scp=84882894435&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882894435&partnerID=8YFLogxK

U2 - 10.1016/B978-008045046-9.01029-9

DO - 10.1016/B978-008045046-9.01029-9

M3 - Chapter

SN - 9780080450469

SP - 785

EP - 791

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -