Cerebral glucose metabolism associated with a fear network in panic disorder

Yojiro Sakai, Hiroaki Kumano, Masami Nishikawa, Yuji Sakano, Hisanobu Kaiya, Etsuko Imabayashi, Takashi Ohnishi, Hiroshi Matsuda, Asako Yasuda, Atsushi Sato, Mirko Diksic, Tomifusa Kuboki

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135 Citations (Scopus)


The present study was performed to assess cerebral glucose metabolism in patients with panic disorder using positron emission tomography. 18F-fluorodeoxyglucose positron emission tomography with voxel-based analysis was used to compare regional brain glucose utilization in 12 nonmedicated panic disorder patients, without their experiencing panic attacks during positron emission tomography acquisition, with that in 22 healthy controls. Panic disorder patients showed appreciably high state anxiety before scanning, and exhibited significantly higher levels of glucose uptake in the bilateral amygdala, hippocampus, and thalamus, and in the midbrain, caudal pons, medulla, and cerebellum than controls. These results provided the first functional neuroimaging support in human patients for the neuroanatomical hypothesis of panic disorder focusing on the amygdala-based fear network.

Original languageEnglish
Pages (from-to)927-931
Number of pages5
Issue number9
Publication statusPublished - 2005 Jun 21



  • Amygdala
  • Anticipatory anxiety
  • Fear network
  • Panic attack
  • Panic disorder
  • Positron emission tomography
  • Regional brain glucose metabolism

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sakai, Y., Kumano, H., Nishikawa, M., Sakano, Y., Kaiya, H., Imabayashi, E., Ohnishi, T., Matsuda, H., Yasuda, A., Sato, A., Diksic, M., & Kuboki, T. (2005). Cerebral glucose metabolism associated with a fear network in panic disorder. NeuroReport, 16(9), 927-931. https://doi.org/10.1097/00001756-200506210-00010