Changes in amygdaloid afterdischarges and kindling effect following olfactory bulbectomy in the rat

Shigenori Watanabe, Hiroshi Nakanishi, Shigenobu Shibata, Showa Ueki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Changes in the thresholds for afterdischarges and the formation of kindling effect in the medial amygdala following olfactory bulbectomy were investigated in the rat with chronic electrode implants. The threshold for afterdischarges in the amygdala of the olfactory bulbectomized rat (OB rat) was significantly decreased on day 4 after olfactory bulbectomy, however, no significant difference was found between OB and sham operated rats on days 7, 14 and 21 since the threshold in the sham group was also decreased at these periods after the surgery. The formation of kindling effect was remarkably accelerated in the OB rats. In this case, the number of days required to reach the stage 1 (Racine's classification) was significantly shortened. These results suggest that the activity of the medial amygdaloid nucleus is increased following olfactory bulbectomy.

Original languageEnglish
Pages (from-to)687-692
Number of pages6
JournalPhysiology and Behavior
Volume28
Issue number4
DOIs
Publication statusPublished - 1982
Externally publishedYes

Fingerprint

Amygdala
Electrodes
Corticomedial Nuclear Complex

Keywords

  • Afterdischarges
  • Amygdala
  • Kindling effect
  • Muricide
  • Olfactory bulbectomy
  • Rat

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Changes in amygdaloid afterdischarges and kindling effect following olfactory bulbectomy in the rat. / Watanabe, Shigenori; Nakanishi, Hiroshi; Shibata, Shigenobu; Ueki, Showa.

In: Physiology and Behavior, Vol. 28, No. 4, 1982, p. 687-692.

Research output: Contribution to journalArticle

Watanabe, Shigenori ; Nakanishi, Hiroshi ; Shibata, Shigenobu ; Ueki, Showa. / Changes in amygdaloid afterdischarges and kindling effect following olfactory bulbectomy in the rat. In: Physiology and Behavior. 1982 ; Vol. 28, No. 4. pp. 687-692.
@article{dbe4eee6cf7840389493dff27651b334,
title = "Changes in amygdaloid afterdischarges and kindling effect following olfactory bulbectomy in the rat",
abstract = "Changes in the thresholds for afterdischarges and the formation of kindling effect in the medial amygdala following olfactory bulbectomy were investigated in the rat with chronic electrode implants. The threshold for afterdischarges in the amygdala of the olfactory bulbectomized rat (OB rat) was significantly decreased on day 4 after olfactory bulbectomy, however, no significant difference was found between OB and sham operated rats on days 7, 14 and 21 since the threshold in the sham group was also decreased at these periods after the surgery. The formation of kindling effect was remarkably accelerated in the OB rats. In this case, the number of days required to reach the stage 1 (Racine's classification) was significantly shortened. These results suggest that the activity of the medial amygdaloid nucleus is increased following olfactory bulbectomy.",
keywords = "Afterdischarges, Amygdala, Kindling effect, Muricide, Olfactory bulbectomy, Rat",
author = "Shigenori Watanabe and Hiroshi Nakanishi and Shigenobu Shibata and Showa Ueki",
year = "1982",
doi = "10.1016/0031-9384(82)90052-X",
language = "English",
volume = "28",
pages = "687--692",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Changes in amygdaloid afterdischarges and kindling effect following olfactory bulbectomy in the rat

AU - Watanabe, Shigenori

AU - Nakanishi, Hiroshi

AU - Shibata, Shigenobu

AU - Ueki, Showa

PY - 1982

Y1 - 1982

N2 - Changes in the thresholds for afterdischarges and the formation of kindling effect in the medial amygdala following olfactory bulbectomy were investigated in the rat with chronic electrode implants. The threshold for afterdischarges in the amygdala of the olfactory bulbectomized rat (OB rat) was significantly decreased on day 4 after olfactory bulbectomy, however, no significant difference was found between OB and sham operated rats on days 7, 14 and 21 since the threshold in the sham group was also decreased at these periods after the surgery. The formation of kindling effect was remarkably accelerated in the OB rats. In this case, the number of days required to reach the stage 1 (Racine's classification) was significantly shortened. These results suggest that the activity of the medial amygdaloid nucleus is increased following olfactory bulbectomy.

AB - Changes in the thresholds for afterdischarges and the formation of kindling effect in the medial amygdala following olfactory bulbectomy were investigated in the rat with chronic electrode implants. The threshold for afterdischarges in the amygdala of the olfactory bulbectomized rat (OB rat) was significantly decreased on day 4 after olfactory bulbectomy, however, no significant difference was found between OB and sham operated rats on days 7, 14 and 21 since the threshold in the sham group was also decreased at these periods after the surgery. The formation of kindling effect was remarkably accelerated in the OB rats. In this case, the number of days required to reach the stage 1 (Racine's classification) was significantly shortened. These results suggest that the activity of the medial amygdaloid nucleus is increased following olfactory bulbectomy.

KW - Afterdischarges

KW - Amygdala

KW - Kindling effect

KW - Muricide

KW - Olfactory bulbectomy

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=0020315506&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020315506&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(82)90052-X

DO - 10.1016/0031-9384(82)90052-X

M3 - Article

VL - 28

SP - 687

EP - 692

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 4

ER -