Changes in expression of NMDA receptor subunit mRNA by perinatal exposure to dioxin

Masaki Kakeyama, Hideko Sone, Chiharu Tohyama

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Since dioxin and related compounds are suspected of affecting permanently the brain function of offspring of human and experimental animals, effects of perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the expression of rat NMDA receptor NR2A and NR2B subunit mRNA were examined. The mRNA quantification by competitive RT-PCR clearly revealed that TCDD inhibited NR2B mRNA expression and enhanced NR2A mRNA expression in the neocortex and hippocampus on postnatal day (PND) 49, whereas these changes in mRNA expression were not found on PND 5. The results demonstrate for the first time that the perinatal exposure to TCDD can alter the molecular basis of brain of offspring in adulthood.

Original languageEnglish
Pages (from-to)4009-4012
Number of pages4
JournalNeuroReport
Volume12
Issue number18
DOIs
Publication statusPublished - 2001 Dec 21

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Keywords

  • Competitive RT-PCR
  • Dioxin
  • NMDA receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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