Changes in serum thrombopoietin levels after splenectomy

Naoaki Ichikawa, Kiyoshi Kitano, Shigetaka Shimodaira, Fumihiro Ishida, Toshiro Ito, Shoji Kajikawa, Tomoyuki Tahara, Takashi Kato, Kendo Kiyosawa

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

To clarify the role of thrombopoietin (c-Mp1 ligand, TPO) in 'hypersplenic' thrombocytopenia, we used an enzyme-linked immunosorbent assay to examine changes in serum TPO levels accompanied with splenectomy in 6 patients with liver cirrhosis, 4 patients with gastric cancer, and 2 patients with lymphoid malignancies. We also measured serum levels of other thrombopoietic cytokines such as interleukin-6 (IL-6) and erythropoietin. Platelet counts reached a maximum at day 14 after splenectomy in all subjects. In patients with liver cirrhosis, a lower elevation of platelet counts was observed compared with that in patients with gastric cancer. Serum TPO levels gradually elevated after splenectomy and reached a maximum 3.5 days after splenectomy in noncirrhotic patients, whereas peak serum TPO levels were delayed until day 7 in the cirrhosis group. IL-6 and erythropoietin showed similar kinetics between cirrhotic and noncirrhotic patients. These findings suggest that transient thrombocytosis after splenectomy may be associated with an alteration in the site of TPO catabolism by platelets from spleen to the blood and that deterioration of TPO production may play a role in thrombocytopenia in liver cirrhosis.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalActa Haematologica
Volume100
Issue number3
DOIs
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Thrombopoietin
Splenectomy
Serum
Liver Cirrhosis
Erythropoietin
Platelet Count
Thrombocytopenia
Stomach Neoplasms
Interleukin-6
Thrombocytosis
Fibrosis
Blood Platelets
Spleen
Enzyme-Linked Immunosorbent Assay
Cytokines
Ligands

Keywords

  • Liver cirrhosis
  • Splenectomy
  • Thrombocytopenia
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology

Cite this

Ichikawa, N., Kitano, K., Shimodaira, S., Ishida, F., Ito, T., Kajikawa, S., ... Kiyosawa, K. (1998). Changes in serum thrombopoietin levels after splenectomy. Acta Haematologica, 100(3), 137-141. https://doi.org/10.1159/000040888

Changes in serum thrombopoietin levels after splenectomy. / Ichikawa, Naoaki; Kitano, Kiyoshi; Shimodaira, Shigetaka; Ishida, Fumihiro; Ito, Toshiro; Kajikawa, Shoji; Tahara, Tomoyuki; Kato, Takashi; Kiyosawa, Kendo.

In: Acta Haematologica, Vol. 100, No. 3, 1998, p. 137-141.

Research output: Contribution to journalArticle

Ichikawa, N, Kitano, K, Shimodaira, S, Ishida, F, Ito, T, Kajikawa, S, Tahara, T, Kato, T & Kiyosawa, K 1998, 'Changes in serum thrombopoietin levels after splenectomy', Acta Haematologica, vol. 100, no. 3, pp. 137-141. https://doi.org/10.1159/000040888
Ichikawa N, Kitano K, Shimodaira S, Ishida F, Ito T, Kajikawa S et al. Changes in serum thrombopoietin levels after splenectomy. Acta Haematologica. 1998;100(3):137-141. https://doi.org/10.1159/000040888
Ichikawa, Naoaki ; Kitano, Kiyoshi ; Shimodaira, Shigetaka ; Ishida, Fumihiro ; Ito, Toshiro ; Kajikawa, Shoji ; Tahara, Tomoyuki ; Kato, Takashi ; Kiyosawa, Kendo. / Changes in serum thrombopoietin levels after splenectomy. In: Acta Haematologica. 1998 ; Vol. 100, No. 3. pp. 137-141.
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