Changes in urine 8-hydroxydeoxyguanosine levels of super-marathon runners during a four-day race period

Zsolt Radák, József Pucsuk, Szilvia Boros, Lorand Josfai, A. W. Taylor

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

We have determined the urinary 8-hydroxydeoxyguanosine (8-OHdG) levels of five well trained supra-marathon runners during a four-day race. The daily running distances of the four-day race were the following; 93 km, 120 km, 56 km and 59 km, respectively. Pre-race and post-race urine samples were collected on each day and analyzed by a monoclonal antibody technique. The urinary 8-OHdG content increased significantly on the first day and tended to decrease from the third day. By the fourth day 8-OHdG content was significantly less than measured on the first three days. The serum creatine kinase activity changed in a similar fashion, showing a large increase (P<0.001) up to the third day when it decreased significantly from the peak value (P<0.05). We conclude that extreme physical exercise causes oxidative DNA damage to well trained athletes. However, repeated extreme exercise- induced oxidative stress does not propagate on increase of urinary 8-OHdG, but rather causes an adaptation leading to normalization of oxidative DNA damage.

Original languageEnglish
Pages (from-to)1763-1767
Number of pages5
JournalLife Sciences
Volume66
Issue number18
DOIs
Publication statusPublished - 2000 Mar 24
Externally publishedYes

Keywords

  • Adaptation
  • DNA damage
  • Free radicals
  • Oxidative stress
  • Prolonged exercise

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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