Characteristics of activated neurons in the suprachiasmatic nucleus when mice become hypothermic during fasting and cold exposure

Yuki Uchida, Ken Tokizawa, Kei Nagashima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cold defense mechanisms in mice are attenuated in the light phase during fasting, resulting in hypothermia. The present study examined whether specific neurons and areas in the SCN are related to the response. Mice were fasted over 47h or remained fed, during which they were placed at 20 or 27°C for 3h in the light or dark phases. Body temperature (Tb) was monitored. After the exposure, immunoreactive (IR) cells of cFos, arginine vasopressin (AVP), and vasoactive intestinal polypeptide (VIP) in the SCN were assessed. Tb at 20°C during fasting was lower in the light phase than in the dark phase. Both AVP/cFos-IR and VIP/cFos-IR cells increased when mice were at 20°C during fasting in the light phase. Such increase was observed in the central part of the SCN. These responses in the SCN may be related to the hypothermia in the light phase.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalNeuroscience Letters
Volume579
DOIs
Publication statusPublished - 2014 Sep 5

Fingerprint

Suprachiasmatic Nucleus
Fasting
Neurons
Light
Arginine Vasopressin
Vasoactive Intestinal Peptide
Hypothermia
Defense Mechanisms
Body Temperature

Keywords

  • AVP
  • CFos
  • Circadian rhythm
  • Cold exposure
  • VIP

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Characteristics of activated neurons in the suprachiasmatic nucleus when mice become hypothermic during fasting and cold exposure. / Uchida, Yuki; Tokizawa, Ken; Nagashima, Kei.

In: Neuroscience Letters, Vol. 579, 05.09.2014, p. 177-182.

Research output: Contribution to journalArticle

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