Characteristics of the sequence effect in Parkinson's disease

Suk Yun Kang, Toshiaki Wasaka, Ejaz A. Shamim, Sungyoung Auh, Yoshino Ueki, Grisel J. Lopez, Tetsuo Kida, Seung Hyun Jin, Nguyet Dang, Mark Hallett

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The sequence effect (SE) in Parkinson's disease (PD) is progressive slowing of sequential movements. It is a feature of bradykinesia, but is separate from a general slowness without deterioration over time. It is commonly seen in PD, but its physiology is unclear. We measured general slowness and the SE separately with a computer-based, modified Purdue pegboard in 11 patients with advanced PD. We conducted a placebo-controlled, four-way crossover study to learn whether levodopa and repetitive transcranial magnetic stimulation (rTMS) could improve general slowness or the SE. We also examined the correlation between the SE and clinical fatigue. Levodopa alone and rTMS alone improved general slowness, but rTMS showed no additive effect on levodopa. Levodopa alone, rTMS alone, and their combination did not alleviate the SE. There was no correlation between the SE and fatigue. This study suggests that dopaminergic dysfunction and abnormal motor cortex excitability are not the relevant mechanisms for the SE. Additionally, the SE is not a component of clinical fatigue. Further work is needed to establish the physiology and clinical relevance of the SE.

Original languageEnglish
Pages (from-to)2148-2155
Number of pages8
JournalMovement Disorders
Volume25
Issue number13
DOIs
Publication statusPublished - 2010 Oct 15

Fingerprint

Transcranial Magnetic Stimulation
Levodopa
Parkinson Disease
Fatigue
Hypokinesia
Motor Cortex
Cross-Over Studies
Placebos

Keywords

  • Fatigue
  • Levodopa
  • Parkinson's disease
  • Pegboard test
  • rTMS
  • Sequence effect

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Kang, S. Y., Wasaka, T., Shamim, E. A., Auh, S., Ueki, Y., Lopez, G. J., ... Hallett, M. (2010). Characteristics of the sequence effect in Parkinson's disease. Movement Disorders, 25(13), 2148-2155. https://doi.org/10.1002/mds.23251

Characteristics of the sequence effect in Parkinson's disease. / Kang, Suk Yun; Wasaka, Toshiaki; Shamim, Ejaz A.; Auh, Sungyoung; Ueki, Yoshino; Lopez, Grisel J.; Kida, Tetsuo; Jin, Seung Hyun; Dang, Nguyet; Hallett, Mark.

In: Movement Disorders, Vol. 25, No. 13, 15.10.2010, p. 2148-2155.

Research output: Contribution to journalArticle

Kang, SY, Wasaka, T, Shamim, EA, Auh, S, Ueki, Y, Lopez, GJ, Kida, T, Jin, SH, Dang, N & Hallett, M 2010, 'Characteristics of the sequence effect in Parkinson's disease', Movement Disorders, vol. 25, no. 13, pp. 2148-2155. https://doi.org/10.1002/mds.23251
Kang SY, Wasaka T, Shamim EA, Auh S, Ueki Y, Lopez GJ et al. Characteristics of the sequence effect in Parkinson's disease. Movement Disorders. 2010 Oct 15;25(13):2148-2155. https://doi.org/10.1002/mds.23251
Kang, Suk Yun ; Wasaka, Toshiaki ; Shamim, Ejaz A. ; Auh, Sungyoung ; Ueki, Yoshino ; Lopez, Grisel J. ; Kida, Tetsuo ; Jin, Seung Hyun ; Dang, Nguyet ; Hallett, Mark. / Characteristics of the sequence effect in Parkinson's disease. In: Movement Disorders. 2010 ; Vol. 25, No. 13. pp. 2148-2155.
@article{62e63158e6fe4e618bad46bf6d4bac99,
title = "Characteristics of the sequence effect in Parkinson's disease",
abstract = "The sequence effect (SE) in Parkinson's disease (PD) is progressive slowing of sequential movements. It is a feature of bradykinesia, but is separate from a general slowness without deterioration over time. It is commonly seen in PD, but its physiology is unclear. We measured general slowness and the SE separately with a computer-based, modified Purdue pegboard in 11 patients with advanced PD. We conducted a placebo-controlled, four-way crossover study to learn whether levodopa and repetitive transcranial magnetic stimulation (rTMS) could improve general slowness or the SE. We also examined the correlation between the SE and clinical fatigue. Levodopa alone and rTMS alone improved general slowness, but rTMS showed no additive effect on levodopa. Levodopa alone, rTMS alone, and their combination did not alleviate the SE. There was no correlation between the SE and fatigue. This study suggests that dopaminergic dysfunction and abnormal motor cortex excitability are not the relevant mechanisms for the SE. Additionally, the SE is not a component of clinical fatigue. Further work is needed to establish the physiology and clinical relevance of the SE.",
keywords = "Fatigue, Levodopa, Parkinson's disease, Pegboard test, rTMS, Sequence effect",
author = "Kang, {Suk Yun} and Toshiaki Wasaka and Shamim, {Ejaz A.} and Sungyoung Auh and Yoshino Ueki and Lopez, {Grisel J.} and Tetsuo Kida and Jin, {Seung Hyun} and Nguyet Dang and Mark Hallett",
year = "2010",
month = "10",
day = "15",
doi = "10.1002/mds.23251",
language = "English",
volume = "25",
pages = "2148--2155",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "13",

}

TY - JOUR

T1 - Characteristics of the sequence effect in Parkinson's disease

AU - Kang, Suk Yun

AU - Wasaka, Toshiaki

AU - Shamim, Ejaz A.

AU - Auh, Sungyoung

AU - Ueki, Yoshino

AU - Lopez, Grisel J.

AU - Kida, Tetsuo

AU - Jin, Seung Hyun

AU - Dang, Nguyet

AU - Hallett, Mark

PY - 2010/10/15

Y1 - 2010/10/15

N2 - The sequence effect (SE) in Parkinson's disease (PD) is progressive slowing of sequential movements. It is a feature of bradykinesia, but is separate from a general slowness without deterioration over time. It is commonly seen in PD, but its physiology is unclear. We measured general slowness and the SE separately with a computer-based, modified Purdue pegboard in 11 patients with advanced PD. We conducted a placebo-controlled, four-way crossover study to learn whether levodopa and repetitive transcranial magnetic stimulation (rTMS) could improve general slowness or the SE. We also examined the correlation between the SE and clinical fatigue. Levodopa alone and rTMS alone improved general slowness, but rTMS showed no additive effect on levodopa. Levodopa alone, rTMS alone, and their combination did not alleviate the SE. There was no correlation between the SE and fatigue. This study suggests that dopaminergic dysfunction and abnormal motor cortex excitability are not the relevant mechanisms for the SE. Additionally, the SE is not a component of clinical fatigue. Further work is needed to establish the physiology and clinical relevance of the SE.

AB - The sequence effect (SE) in Parkinson's disease (PD) is progressive slowing of sequential movements. It is a feature of bradykinesia, but is separate from a general slowness without deterioration over time. It is commonly seen in PD, but its physiology is unclear. We measured general slowness and the SE separately with a computer-based, modified Purdue pegboard in 11 patients with advanced PD. We conducted a placebo-controlled, four-way crossover study to learn whether levodopa and repetitive transcranial magnetic stimulation (rTMS) could improve general slowness or the SE. We also examined the correlation between the SE and clinical fatigue. Levodopa alone and rTMS alone improved general slowness, but rTMS showed no additive effect on levodopa. Levodopa alone, rTMS alone, and their combination did not alleviate the SE. There was no correlation between the SE and fatigue. This study suggests that dopaminergic dysfunction and abnormal motor cortex excitability are not the relevant mechanisms for the SE. Additionally, the SE is not a component of clinical fatigue. Further work is needed to establish the physiology and clinical relevance of the SE.

KW - Fatigue

KW - Levodopa

KW - Parkinson's disease

KW - Pegboard test

KW - rTMS

KW - Sequence effect

UR - http://www.scopus.com/inward/record.url?scp=78649369420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649369420&partnerID=8YFLogxK

U2 - 10.1002/mds.23251

DO - 10.1002/mds.23251

M3 - Article

C2 - 20669182

AN - SCOPUS:78649369420

VL - 25

SP - 2148

EP - 2155

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 13

ER -