Characterization of amyloid β protein species in cerebral amyloid angiopathy of a squirrel monkey by immunocytochemistry and enzyme-linked immunosorbent assay

Naoya Sawamura, Akira Tamaoka, Shi N.Ichi Shoji, Edward H. Koo, Lary C. Walker, Hiroshi Mori

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

We analyzed the composition of amyloid β protein (A β) species in cerebral amyloid angiopathy (CAA) of an aged squirrel monkey. Immunocytochemistry demonstrated that the cerebral cortex contained no lesions other than widespread CAA with A β40 as its apparent major component. However, enzyme-linked immunosorbent assay revealed that A β42(43) predominated over A β40 in a formic acid-extracted cortical fraction. These findings suggest possible underestimation of A β42(43) levels in some previous immunocytochemical investigations.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalBrain Research
Volume764
Issue number1-2
DOIs
Publication statusPublished - 1997 Aug 1
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid β protein
  • Cerebral amyloid angiopathy
  • Enzyme-linked immunosorbent assay
  • Immunocytochemistry
  • Squirrel monkey

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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