Characterization of hybridization on diamond solution-gate field-effect transistors for detecting single mismatched oligonucleotides

Jung Hoon Yang, Shouma Kuga, Kwang Soup Song, Hiroshi Kawarada

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Using diamond field-effect transistors (FETs) operated in electrolyte solution (solution-gate FETs; SGFETs), a label-free charge detection method between complementary and single mismatched target oligonucleotides is proposed. The probe oligonucleotides immobilized at the activated carboxyl groups of carboxylic aromatic compounds (CACs) on the previously formed amino groups of the diamond surface. The high performance of the diamond surface for oligonucleotides detection was studied with respect to selectivity, sensitivity, and reproducibility of the diamond SGFETs.

Original languageEnglish
Pages (from-to)1180011-1180013
Number of pages3
JournalApplied Physics Express
Volume1
Issue number11
DOIs
Publication statusPublished - 2008 Nov 1

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ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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