Charged polymers via controlled radical polymerization and their implications for gene delivery

William H. Heath, Askim F. Senyurt, John Layman, Timothy Edward Long

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Non-viral gene delivery agents are notorious for their poor nucleic acid transfection efficiency and relatively high cell cytotoxicity. Thus, many investigators are exploring the important parameters involved in charged polymer-mediated gene delivery, such as chemical composition, molecular weight, structural architecture, surface charge, etc. It is important to develop clear structure-property relationships in order to design successful nucleic acid delivery agents for gene therapy. To elucidate these relationships, well-defined materials are necessary. Controlled radical polymerization methods offer a facile route to systematically produce well-defined, structurally distinct gene delivery agents. The use of charged polymers prepared via controlled radical polymerizations to elucidate transfection mechanisms or develop new delivery vectors will be reviewed herein.

Original languageEnglish
Pages (from-to)1243-1249
Number of pages7
JournalMacromolecular Chemistry and Physics
Volume208
Issue number12
DOIs
Publication statusPublished - 2007 Jun 19
Externally publishedYes

Fingerprint

Free radical polymerization
genes
delivery
Polymers
polymerization
Genes
Nucleic acids
Nucleic Acids
polymers
nucleic acids
Gene therapy
Cytotoxicity
Surface charge
gene therapy
Molecular weight
molecular weight
Chemical analysis
chemical composition
routes
cells

Keywords

  • Biopolymers
  • Charged polymers
  • Controlled polymerizations
  • Gene delivery
  • Polyelectrolytes

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this

Charged polymers via controlled radical polymerization and their implications for gene delivery. / Heath, William H.; Senyurt, Askim F.; Layman, John; Long, Timothy Edward.

In: Macromolecular Chemistry and Physics, Vol. 208, No. 12, 19.06.2007, p. 1243-1249.

Research output: Contribution to journalArticle

Heath, William H. ; Senyurt, Askim F. ; Layman, John ; Long, Timothy Edward. / Charged polymers via controlled radical polymerization and their implications for gene delivery. In: Macromolecular Chemistry and Physics. 2007 ; Vol. 208, No. 12. pp. 1243-1249.
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