Chemo-mechanical coupling in the rotary molecular motor f1-atpase

Kengo Adachi, Shou Furuike, Mohammad Delawar Hossain, Hiroyasu Itoh, Kazuhiko Kinosita, Yasuhiro Onoue, Rieko Shimo-Kon

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

F1-ATPase is a molecular motor in which the central γ subunit rotates inside the cylinder made of α3β3 subunits. The rotation is powered by ATP hydrolysis in three catalytic sites, and reverse rotation of the γ subunit by an external force leads to ATP synthesis in the catalytic sites. Single-molecule studies have revealed how the mechanical rotation is coupled to the chemical reactions in the three catalytic sites: binding/release of ATP, ADP, and phosphate, and hydrolysis/synthesis of ATP.

Original languageEnglish
Title of host publicationSpringer Series in Chemical Physics
Pages272-285
Number of pages14
Volume96
Publication statusPublished - 2010
Externally publishedYes

Publication series

NameSpringer Series in Chemical Physics
Volume96
ISSN (Print)01726218

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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