@article{2c6cfb20ff954945bf872a4a8d1aee63,
title = "Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption",
abstract = "Rapid eye movement (REM) sleep loss is associated with increased consumption of weight-promoting foods. The prefrontal cortex (PFC) is thought to mediate reward anticipation. However, the precise role of the PFC in mediating reward responses to highly palatable foods (HPF) after REM sleep deprivation is unclear. We selectively reduced REM sleep in mice over a 25-48 hr period and chemogenetically inhibited the medial PFC (mPFC) by using an altered glutamategated and ivermectin-gated chloride channel that facilitated neuronal inhibition through hyperpolarizing infected neurons. HPF consumption was measured while the mPFC was inactivated and REM sleep loss was induced. We found that REM sleep loss increased HPF consumption compared to control animals. However, mPFC inactivation reversed the effect of REM sleep loss on sucrose consumption without affecting fat consumption. Our findings provide, for the first time, a causal link between REM sleep, mPFC function and HPF consumption.",
author = "Kristopher McEown and Yohko Takata and Yoan Cherasse and Nanae Nagata and Kosuke Aritake and Michael Lazarus",
note = "Funding Information: This work was supported by a Japan Society for the Promotion of Science KAKENHI grant (2604762, to ML) and postdoctoral fellowship (P14762, to KM); a Takeda Science Foundation postdoctoral fellowship (to KM); a grant from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan (Grant-in-Aid for Scientific Research on Innovative Areas {\textquoteleft}Living in Space{\textquoteright}, 16H01629, to ML); a CREST grant from the Japan Science and Technology Agency (to ML) and the World Premier International Research Center Initiative (WPI) from MEXT (to ML, YT, YC, NN and KA). Japan Society for the Promotion of Science P14762 Kristopher McEown Japan Society for the Promotion of Science 2604762 Michael Lazarus Ministry of Education, Culture, Sports, Science, and Technology 16H01629 Michael Lazarus Japan Science and Technology Agency 16814578 Michael Lazarus The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publisher Copyright: {\textcopyright} McEown et al.",
year = "2016",
month = dec,
day = "6",
doi = "10.7554/eLife.20269",
language = "English",
volume = "5",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
number = "DECEMBER2016",
}