Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption

Kristopher Scott McEown, Yohko Takata, Yoan Cherasse, Nanae Nagata, Kosuke Aritake, Michael Lazarus

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Rapid eye movement (REM) sleep loss is associated with increased consumption of weight-promoting foods. The prefrontal cortex (PFC) is thought to mediate reward anticipation. However, the precise role of the PFC in mediating reward responses to highly palatable foods (HPF) after REM sleep deprivation is unclear. We selectively reduced REM sleep in mice over a 25-48 hr period and chemogenetically inhibited the medial PFC (mPFC) by using an altered glutamategated and ivermectin-gated chloride channel that facilitated neuronal inhibition through hyperpolarizing infected neurons. HPF consumption was measured while the mPFC was inactivated and REM sleep loss was induced. We found that REM sleep loss increased HPF consumption compared to control animals. However, mPFC inactivation reversed the effect of REM sleep loss on sucrose consumption without affecting fat consumption. Our findings provide, for the first time, a causal link between REM sleep, mPFC function and HPF consumption.

Original languageEnglish
Article numbere20269
JournaleLife
Volume5
Issue numberDECEMBER2016
DOIs
Publication statusPublished - 2016 Dec 6
Externally publishedYes

Fingerprint

Eye movements
REM Sleep
Prefrontal Cortex
Sucrose
Sleep
Food
Reward
Ivermectin
Chloride Channels
Sleep Deprivation
Inhibition (Psychology)
Neurons
Animals
Fats
Weights and Measures

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption. / McEown, Kristopher Scott; Takata, Yohko; Cherasse, Yoan; Nagata, Nanae; Aritake, Kosuke; Lazarus, Michael.

In: eLife, Vol. 5, No. DECEMBER2016, e20269, 06.12.2016.

Research output: Contribution to journalArticle

McEown, Kristopher Scott ; Takata, Yohko ; Cherasse, Yoan ; Nagata, Nanae ; Aritake, Kosuke ; Lazarus, Michael. / Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption. In: eLife. 2016 ; Vol. 5, No. DECEMBER2016.
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