Chemoselective Suzuki coupling of diborylmethane for facile synthesis of benzylboronates

Kohei Endo, Takahiro Ohkubo, Takanori Shibata

    Research output: Contribution to journal › Article

    70 Citations (Scopus)

    Abstract

    The chemoselective Pd-catalyzed Suzuki-Miyaura cross-coupling reaction using a diborylmethane is reported. The use of an equimolar amount of base with a diborylmethane realized chemoselective coupling for the synthesis of various benzylboronate derivatives. Sterically hindered aryl bromides can give products in moderate to excellent yields.

    Original languageEnglish
    Pages (from-to)3368-3371
    Number of pages4
    JournalOrganic Letters
    Volume13
    Issue number13
    DOIs
    Publication statusPublished - 2011 Jul 1

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    cross coupling
    Cross Reactions
    Bromides
    bromides
    Derivatives
    synthesis
    products

    ASJC Scopus subject areas

    • Organic Chemistry
    • Physical and Theoretical Chemistry
    • Biochemistry

    Cite this

    Chemoselective Suzuki coupling of diborylmethane for facile synthesis of benzylboronates. / Endo, Kohei; Ohkubo, Takahiro; Shibata, Takanori.

    In: Organic Letters, Vol. 13, No. 13, 01.07.2011, p. 3368-3371.

    Research output: Contribution to journal › Article

    Endo, K, Ohkubo, T & Shibata, T 2011, 'Chemoselective Suzuki coupling of diborylmethane for facile synthesis of benzylboronates', Organic Letters, vol. 13, no. 13, pp. 3368-3371. https://doi.org/10.1021/ol201115k
    Endo K, Ohkubo T, Shibata T. Chemoselective Suzuki coupling of diborylmethane for facile synthesis of benzylboronates. Organic Letters. 2011 Jul 1;13(13):3368-3371. https://doi.org/10.1021/ol201115k
    Endo, Kohei ; Ohkubo, Takahiro ; Shibata, Takanori. / Chemoselective Suzuki coupling of diborylmethane for facile synthesis of benzylboronates. In: Organic Letters. 2011 ; Vol. 13, No. 13. pp. 3368-3371.
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