Chemoselective Suzuki coupling of diborylmethane for facile synthesis of benzylboronates

Kohei Endo; Takahiro Ohkubo; Takanori Shibata

doi:10.1021/ol201115k

Chemoselective Suzuki coupling of diborylmethane for facile synthesis of benzylboronates

Kohei Endo^*, Takahiro Ohkubo, Takanori Shibata

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

The chemoselective Pd-catalyzed Suzuki-Miyaura cross-coupling reaction using a diborylmethane is reported. The use of an equimolar amount of base with a diborylmethane realized chemoselective coupling for the synthesis of various benzylboronate derivatives. Sterically hindered aryl bromides can give products in moderate to excellent yields.

Original language	English
Pages (from-to)	3368-3371
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	13
DOIs	https://doi.org/10.1021/ol201115k
Publication status	Published - 2011 Jul 1

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol201115k

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title = "Chemoselective Suzuki coupling of diborylmethane for facile synthesis of benzylboronates",

abstract = "The chemoselective Pd-catalyzed Suzuki-Miyaura cross-coupling reaction using a diborylmethane is reported. The use of an equimolar amount of base with a diborylmethane realized chemoselective coupling for the synthesis of various benzylboronate derivatives. Sterically hindered aryl bromides can give products in moderate to excellent yields.",

author = "Kohei Endo and Takahiro Ohkubo and Takanori Shibata",

year = "2011",

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doi = "10.1021/ol201115k",

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volume = "13",

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journal = "Organic Letters",

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T1 - Chemoselective Suzuki coupling of diborylmethane for facile synthesis of benzylboronates

AU - Endo, Kohei

AU - Ohkubo, Takahiro

AU - Shibata, Takanori

PY - 2011/7/1

Y1 - 2011/7/1

N2 - The chemoselective Pd-catalyzed Suzuki-Miyaura cross-coupling reaction using a diborylmethane is reported. The use of an equimolar amount of base with a diborylmethane realized chemoselective coupling for the synthesis of various benzylboronate derivatives. Sterically hindered aryl bromides can give products in moderate to excellent yields.

AB - The chemoselective Pd-catalyzed Suzuki-Miyaura cross-coupling reaction using a diborylmethane is reported. The use of an equimolar amount of base with a diborylmethane realized chemoselective coupling for the synthesis of various benzylboronate derivatives. Sterically hindered aryl bromides can give products in moderate to excellent yields.

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JF - Organic Letters

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Chemoselective Suzuki coupling of diborylmethane for facile synthesis of benzylboronates

Abstract

ASJC Scopus subject areas

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