Chiba study of mother and children's health (C-MACH): Cohort study with omics analyses

On behalf of the Chiba study of Mother and Children's Health group

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: Recent epidemiological studies have shown that environmental factors during the fetal period to early childhood might affect the risk of noncommunicable diseases in adulthood. This is referred to as the developmental origins of health and disease (DOHaD) concept. The Chiba study of Mother and Children's Health (C-MACH) is a birth cohort study based on the DOHaD hypothesis and involves multiomics analysis. This study aims to explore the effects of genetic and environmental factors-particularly the fetal environment and postbirth living environment-on children's health, and to identify potential biomarkers for these effects. Participants: The C-MACH consists of three hospitalbased cohorts. The study participants are pregnant women at 2. Before pregnancy, 72.3% of the women had a BMI of 18.5-24.9 kg/m2. During early pregnancy, 5.0% of the participants smoked. Future plans: Primary outcomes are allergy, obesity, endocrine and metabolic disorders, and developmental disorders. Genome-level, metabolome-level, umbilical cord DNA methylation (epigenome), gut microbiota and environmental chemical exposure variables will be evaluated. We will analyse the relationships between the outcomes and analytical variables.

Original languageEnglish
Article numbere010531
JournalBMJ Open
Volume6
Issue number1
DOIs
Publication statusPublished - 2016
Externally publishedYes

Fingerprint

Cohort Studies
Mothers
Pregnancy
Metabolome
Umbilical Cord
Environmental Exposure
Health
DNA Methylation
Pregnant Women
Epidemiologic Studies
Hypersensitivity
Obesity
Biomarkers
Parturition
Genome
Child Health
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

On behalf of the Chiba study of Mother and Children's Health group (2016). Chiba study of mother and children's health (C-MACH): Cohort study with omics analyses. BMJ Open, 6(1), [e010531]. https://doi.org/10.1136/bmjopen-2015-010531

Chiba study of mother and children's health (C-MACH) : Cohort study with omics analyses. / On behalf of the Chiba study of Mother and Children's Health group.

In: BMJ Open, Vol. 6, No. 1, e010531, 2016.

Research output: Contribution to journalArticle

On behalf of the Chiba study of Mother and Children's Health group 2016, 'Chiba study of mother and children's health (C-MACH): Cohort study with omics analyses', BMJ Open, vol. 6, no. 1, e010531. https://doi.org/10.1136/bmjopen-2015-010531
On behalf of the Chiba study of Mother and Children's Health group. Chiba study of mother and children's health (C-MACH): Cohort study with omics analyses. BMJ Open. 2016;6(1). e010531. https://doi.org/10.1136/bmjopen-2015-010531
On behalf of the Chiba study of Mother and Children's Health group. / Chiba study of mother and children's health (C-MACH) : Cohort study with omics analyses. In: BMJ Open. 2016 ; Vol. 6, No. 1.
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AU - Sakurai, Kenichi

AU - Miyaso, Hidenobu

AU - Eguchi, Akifumi

AU - Matsuno, Yoshiharu

AU - Yamamoto, Midori

AU - Todaka, Emiko

AU - Fukuoka, Hideoki

AU - Hata, Akira

AU - Mori, Chisato

AU - Sekine, Akihiro

AU - Fujita, Shinsuke

AU - Shimojo, Naoki

AU - Hanazato, Masamichi

AU - Tachibana, Kaori

AU - Nakaoka, Hiroko

AU - Otake, Masae

AU - Suzuki, Norimichi

AU - Watanabe, Masahiro

AU - Osada, Hisao

AU - Shiga, Satomi

AU - Kawanami, Akiko

AU - Takase, Shunya

AU - Koga, Chie

AU - Nakamura, Kiminori

AU - Shinohara, Kazuyuki

AU - Kakeyama, Masaki

AU - Doi, Hirokazu

AU - Sawano, Erika

AU - Tsuji, Toshio

AU - Soh, Zu

AU - Shimatani, Koji

AU - Yamaguchi, Satoru

AU - Onodera, Tsutomu

AU - Yamada., Takuhiro

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N2 - Purpose: Recent epidemiological studies have shown that environmental factors during the fetal period to early childhood might affect the risk of noncommunicable diseases in adulthood. This is referred to as the developmental origins of health and disease (DOHaD) concept. The Chiba study of Mother and Children's Health (C-MACH) is a birth cohort study based on the DOHaD hypothesis and involves multiomics analysis. This study aims to explore the effects of genetic and environmental factors-particularly the fetal environment and postbirth living environment-on children's health, and to identify potential biomarkers for these effects. Participants: The C-MACH consists of three hospitalbased cohorts. The study participants are pregnant women at 2. Before pregnancy, 72.3% of the women had a BMI of 18.5-24.9 kg/m2. During early pregnancy, 5.0% of the participants smoked. Future plans: Primary outcomes are allergy, obesity, endocrine and metabolic disorders, and developmental disorders. Genome-level, metabolome-level, umbilical cord DNA methylation (epigenome), gut microbiota and environmental chemical exposure variables will be evaluated. We will analyse the relationships between the outcomes and analytical variables.

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