Chiba study of mother and children's health (C-MACH): Cohort study with omics analyses

On behalf of the Chiba study of Mother and Children's Health group

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Purpose: Recent epidemiological studies have shown that environmental factors during the fetal period to early childhood might affect the risk of noncommunicable diseases in adulthood. This is referred to as the developmental origins of health and disease (DOHaD) concept. The Chiba study of Mother and Children's Health (C-MACH) is a birth cohort study based on the DOHaD hypothesis and involves multiomics analysis. This study aims to explore the effects of genetic and environmental factors-particularly the fetal environment and postbirth living environment-on children's health, and to identify potential biomarkers for these effects. Participants: The C-MACH consists of three hospitalbased cohorts. The study participants are pregnant women at 2. Before pregnancy, 72.3% of the women had a BMI of 18.5-24.9 kg/m2. During early pregnancy, 5.0% of the participants smoked. Future plans: Primary outcomes are allergy, obesity, endocrine and metabolic disorders, and developmental disorders. Genome-level, metabolome-level, umbilical cord DNA methylation (epigenome), gut microbiota and environmental chemical exposure variables will be evaluated. We will analyse the relationships between the outcomes and analytical variables.

Original languageEnglish
Article numbere010531
JournalBMJ Open
Volume6
Issue number1
DOIs
Publication statusPublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    On behalf of the Chiba study of Mother and Children's Health group (2016). Chiba study of mother and children's health (C-MACH): Cohort study with omics analyses. BMJ Open, 6(1), [e010531]. https://doi.org/10.1136/bmjopen-2015-010531