Abstract
In the presence of various chiral secondary alcohols as chiral initiators, an enantioselective alkylation of a pyrimidine-5-carbaldehyde using diisopropylzinc was examined: a pyrimidyl alkanol was obtained in high yield and enantiomeric excess. The correlation between the absolute configuration of the chiral secondary alcohols and the pyrimidyl alkanol is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 1759-1762 |
| Number of pages | 4 |
| Journal | Tetrahedron Asymmetry |
| Volume | 18 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 2007 Aug 9 |
ASJC Scopus subject areas
- Catalysis
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
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Shibata, T., Iwahashi, K., Kawasaki, T., & Soai, K. (2007). Chiral secondary alcohol-induced asymmetric autocatalysis: correlation between the absolute configuration of the chiral initiators and the product. Tetrahedron Asymmetry, 18(15), 1759-1762. https://doi.org/10.1016/j.tetasy.2007.07.030