Chiral secondary alcohol-induced asymmetric autocatalysis: correlation between the absolute configuration of the chiral initiators and the product

Takanori Shibata, Kimiko Iwahashi, Tsuneomi Kawasaki, Kenso Soai

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In the presence of various chiral secondary alcohols as chiral initiators, an enantioselective alkylation of a pyrimidine-5-carbaldehyde using diisopropylzinc was examined: a pyrimidyl alkanol was obtained in high yield and enantiomeric excess. The correlation between the absolute configuration of the chiral secondary alcohols and the pyrimidyl alkanol is discussed.

Original languageEnglish
Pages (from-to)1759-1762
Number of pages4
JournalTetrahedron Asymmetry
Volume18
Issue number15
DOIs
Publication statusPublished - 2007 Aug 9

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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