Chiral secondary alcohol-induced asymmetric autocatalysis: correlation between the absolute configuration of the chiral initiators and the product

Takanori Shibata, Kimiko Iwahashi, Tsuneomi Kawasaki, Kenso Soai

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    21 Citations (Scopus)

    Abstract

    In the presence of various chiral secondary alcohols as chiral initiators, an enantioselective alkylation of a pyrimidine-5-carbaldehyde using diisopropylzinc was examined: a pyrimidyl alkanol was obtained in high yield and enantiomeric excess. The correlation between the absolute configuration of the chiral secondary alcohols and the pyrimidyl alkanol is discussed.

    Original languageEnglish
    Pages (from-to)1759-1762
    Number of pages4
    JournalTetrahedron Asymmetry
    Volume18
    Issue number15
    DOIs
    Publication statusPublished - 2007 Aug 9

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    ASJC Scopus subject areas

    • Inorganic Chemistry
    • Organic Chemistry
    • Materials Chemistry
    • Drug Discovery

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