Chiral secondary alcohol-induced asymmetric autocatalysis: correlation between the absolute configuration of the chiral initiators and the product

Takanori Shibata; Kimiko Iwahashi; Tsuneomi Kawasaki; Kenso Soai

doi:10.1016/j.tetasy.2007.07.030

Chiral secondary alcohol-induced asymmetric autocatalysis: correlation between the absolute configuration of the chiral initiators and the product

Takanori Shibata, Kimiko Iwahashi, Tsuneomi Kawasaki, Kenso Soai

Research output: Contribution to journal › Article

21 Citations (Scopus)

Abstract

In the presence of various chiral secondary alcohols as chiral initiators, an enantioselective alkylation of a pyrimidine-5-carbaldehyde using diisopropylzinc was examined: a pyrimidyl alkanol was obtained in high yield and enantiomeric excess. The correlation between the absolute configuration of the chiral secondary alcohols and the pyrimidyl alkanol is discussed.

Original language	English
Pages (from-to)	1759-1762
Number of pages	4
Journal	Tetrahedron Asymmetry
Volume	18
Issue number	15
DOIs	https://doi.org/10.1016/j.tetasy.2007.07.030
Publication status	Published - 2007 Aug 9

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ASJC Scopus subject areas

Inorganic Chemistry
Organic Chemistry
Materials Chemistry
Drug Discovery

Cite this

Shibata, T., Iwahashi, K., Kawasaki, T., & Soai, K. (2007). Chiral secondary alcohol-induced asymmetric autocatalysis: correlation between the absolute configuration of the chiral initiators and the product. Tetrahedron Asymmetry, 18(15), 1759-1762. https://doi.org/10.1016/j.tetasy.2007.07.030

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Access to Document

10.1016/j.tetasy.2007.07.030