Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis

Kiichiro Taniguchi, Reo Maeda, Tadashi Ando, Takashi Okumura, Naotaka Nakazawa, Ryo Hatori, Mitsutoshi Nakamura, Shunya Hozumi, Hiroo Fujiwara, Kenji Matsuno

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Some organs in animals display left-right (LR) asymmetry. To better understand LR asymmetric morphogenesis in Drosophila, we studied LR directional rotation of the hindgut epithelial tube. Hindgut epithelial cells adopt a LR asymmetric (chiral) cell shape within their plane, and we refer to this cell behavior as planar cell-shape chirality (PCC). Drosophila E-cadherin (DE-Cad) is distributed to cell boundaries with LR asymmetry, which is responsible for the PCC formation. Myosin ID switches the LR polarity found in PCC and in DE-Cad distribution, which coincides with the direction of rotation. An in silico simulation showed that PCC is sufficient to induce the directional rotation of this tissue. Thus, the intrinsic chirality of epithelial cells in vivo is an underlying mechanism for LR asymmetric tissue morphogenesis.

Original languageEnglish
Pages (from-to)339-341
Number of pages3
JournalScience
Volume333
Issue number6040
DOIs
Publication statusPublished - 2011 Jul 15
Externally publishedYes

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Cell Shape
Morphogenesis
Drosophila
Cadherins
Epithelial Cells
Animal Structures
Myosins
Computer Simulation

ASJC Scopus subject areas

  • General

Cite this

Taniguchi, K., Maeda, R., Ando, T., Okumura, T., Nakazawa, N., Hatori, R., ... Matsuno, K. (2011). Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis. Science, 333(6040), 339-341. https://doi.org/10.1126/science.1200940

Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis. / Taniguchi, Kiichiro; Maeda, Reo; Ando, Tadashi; Okumura, Takashi; Nakazawa, Naotaka; Hatori, Ryo; Nakamura, Mitsutoshi; Hozumi, Shunya; Fujiwara, Hiroo; Matsuno, Kenji.

In: Science, Vol. 333, No. 6040, 15.07.2011, p. 339-341.

Research output: Contribution to journalArticle

Taniguchi, K, Maeda, R, Ando, T, Okumura, T, Nakazawa, N, Hatori, R, Nakamura, M, Hozumi, S, Fujiwara, H & Matsuno, K 2011, 'Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis', Science, vol. 333, no. 6040, pp. 339-341. https://doi.org/10.1126/science.1200940
Taniguchi K, Maeda R, Ando T, Okumura T, Nakazawa N, Hatori R et al. Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis. Science. 2011 Jul 15;333(6040):339-341. https://doi.org/10.1126/science.1200940
Taniguchi, Kiichiro ; Maeda, Reo ; Ando, Tadashi ; Okumura, Takashi ; Nakazawa, Naotaka ; Hatori, Ryo ; Nakamura, Mitsutoshi ; Hozumi, Shunya ; Fujiwara, Hiroo ; Matsuno, Kenji. / Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis. In: Science. 2011 ; Vol. 333, No. 6040. pp. 339-341.
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