Chronic administration of methamphetamine does not affect the suprachiasmatic nucleus-operated circadian pacemaker in rats

Takahiro Moriya, Tatsuto Fukushima, Takao Shimazoe, Shigenobu Shibata, Shigenori Watanabe

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    The effects of chronic administration of methamphetamine (MAP) on rat locomotor activity rhythm under light-dark (LD) housing and on neuronal activity rhythms from the suprachiasmatic nucleus (SCN) in vitro were investigated. Control rats exhibited an LD-entrained nocturnal locomotor rhythm. The firing rate of SCN neuronal activity was high during the light period and low during the dark period in control normal rats, and peak of firing activity occurred around zeitgeber time (ZT) 6. On the other hand, chronic MAP administration caused various disorganization of locomotor activity rhythms with a long free-running period (25-35 h). Neuronal activity rhythms of the SCN were unaffected by chronic MAP administration, that is, high during the light period and low during the dark period. The present findings suggested that the SCN maintained as a circadian pacemaker even under chronic MAP administration which affected overt rhythms.

    Original languageEnglish
    Pages (from-to)129-132
    Number of pages4
    JournalNeuroscience Letters
    Issue number2
    Publication statusPublished - 1996 Apr 19



    • circadian rhythm
    • circadian rhythm
    • methamphetamine
    • rat
    • suprachiasmatic nucleus

    ASJC Scopus subject areas

    • Neuroscience(all)

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