Chronic administration of methamphetamine does not affect the suprachiasmatic nucleus-operated circadian pacemaker in rats

Takahiro Moriya, Tatsuto Fukushima, Takao Shimazoe, Shigenobu Shibata, Shigenori Watanabe

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    The effects of chronic administration of methamphetamine (MAP) on rat locomotor activity rhythm under light-dark (LD) housing and on neuronal activity rhythms from the suprachiasmatic nucleus (SCN) in vitro were investigated. Control rats exhibited an LD-entrained nocturnal locomotor rhythm. The firing rate of SCN neuronal activity was high during the light period and low during the dark period in control normal rats, and peak of firing activity occurred around zeitgeber time (ZT) 6. On the other hand, chronic MAP administration caused various disorganization of locomotor activity rhythms with a long free-running period (25-35 h). Neuronal activity rhythms of the SCN were unaffected by chronic MAP administration, that is, high during the light period and low during the dark period. The present findings suggested that the SCN maintained as a circadian pacemaker even under chronic MAP administration which affected overt rhythms.

    Original languageEnglish
    Pages (from-to)129-132
    Number of pages4
    JournalNeuroscience Letters
    Volume208
    Issue number2
    DOIs
    Publication statusPublished - 1996 Apr 19

    Fingerprint

    Suprachiasmatic Nucleus
    Methamphetamine
    Light
    Locomotion

    Keywords

    • circadian rhythm
    • circadian rhythm
    • methamphetamine
    • rat
    • suprachiasmatic nucleus

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Chronic administration of methamphetamine does not affect the suprachiasmatic nucleus-operated circadian pacemaker in rats. / Moriya, Takahiro; Fukushima, Tatsuto; Shimazoe, Takao; Shibata, Shigenobu; Watanabe, Shigenori.

    In: Neuroscience Letters, Vol. 208, No. 2, 19.04.1996, p. 129-132.

    Research output: Contribution to journalArticle

    Moriya, Takahiro ; Fukushima, Tatsuto ; Shimazoe, Takao ; Shibata, Shigenobu ; Watanabe, Shigenori. / Chronic administration of methamphetamine does not affect the suprachiasmatic nucleus-operated circadian pacemaker in rats. In: Neuroscience Letters. 1996 ; Vol. 208, No. 2. pp. 129-132.
    @article{0d2a768b1b6541b7818270724e43cf40,
    title = "Chronic administration of methamphetamine does not affect the suprachiasmatic nucleus-operated circadian pacemaker in rats",
    abstract = "The effects of chronic administration of methamphetamine (MAP) on rat locomotor activity rhythm under light-dark (LD) housing and on neuronal activity rhythms from the suprachiasmatic nucleus (SCN) in vitro were investigated. Control rats exhibited an LD-entrained nocturnal locomotor rhythm. The firing rate of SCN neuronal activity was high during the light period and low during the dark period in control normal rats, and peak of firing activity occurred around zeitgeber time (ZT) 6. On the other hand, chronic MAP administration caused various disorganization of locomotor activity rhythms with a long free-running period (25-35 h). Neuronal activity rhythms of the SCN were unaffected by chronic MAP administration, that is, high during the light period and low during the dark period. The present findings suggested that the SCN maintained as a circadian pacemaker even under chronic MAP administration which affected overt rhythms.",
    keywords = "circadian rhythm, circadian rhythm, methamphetamine, rat, suprachiasmatic nucleus",
    author = "Takahiro Moriya and Tatsuto Fukushima and Takao Shimazoe and Shigenobu Shibata and Shigenori Watanabe",
    year = "1996",
    month = "4",
    day = "19",
    doi = "10.1016/0304-3940(96)12565-9",
    language = "English",
    volume = "208",
    pages = "129--132",
    journal = "Neuroscience Letters",
    issn = "0304-3940",
    publisher = "Elsevier Ireland Ltd",
    number = "2",

    }

    TY - JOUR

    T1 - Chronic administration of methamphetamine does not affect the suprachiasmatic nucleus-operated circadian pacemaker in rats

    AU - Moriya, Takahiro

    AU - Fukushima, Tatsuto

    AU - Shimazoe, Takao

    AU - Shibata, Shigenobu

    AU - Watanabe, Shigenori

    PY - 1996/4/19

    Y1 - 1996/4/19

    N2 - The effects of chronic administration of methamphetamine (MAP) on rat locomotor activity rhythm under light-dark (LD) housing and on neuronal activity rhythms from the suprachiasmatic nucleus (SCN) in vitro were investigated. Control rats exhibited an LD-entrained nocturnal locomotor rhythm. The firing rate of SCN neuronal activity was high during the light period and low during the dark period in control normal rats, and peak of firing activity occurred around zeitgeber time (ZT) 6. On the other hand, chronic MAP administration caused various disorganization of locomotor activity rhythms with a long free-running period (25-35 h). Neuronal activity rhythms of the SCN were unaffected by chronic MAP administration, that is, high during the light period and low during the dark period. The present findings suggested that the SCN maintained as a circadian pacemaker even under chronic MAP administration which affected overt rhythms.

    AB - The effects of chronic administration of methamphetamine (MAP) on rat locomotor activity rhythm under light-dark (LD) housing and on neuronal activity rhythms from the suprachiasmatic nucleus (SCN) in vitro were investigated. Control rats exhibited an LD-entrained nocturnal locomotor rhythm. The firing rate of SCN neuronal activity was high during the light period and low during the dark period in control normal rats, and peak of firing activity occurred around zeitgeber time (ZT) 6. On the other hand, chronic MAP administration caused various disorganization of locomotor activity rhythms with a long free-running period (25-35 h). Neuronal activity rhythms of the SCN were unaffected by chronic MAP administration, that is, high during the light period and low during the dark period. The present findings suggested that the SCN maintained as a circadian pacemaker even under chronic MAP administration which affected overt rhythms.

    KW - circadian rhythm

    KW - circadian rhythm

    KW - methamphetamine

    KW - rat

    KW - suprachiasmatic nucleus

    UR - http://www.scopus.com/inward/record.url?scp=0029931989&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0029931989&partnerID=8YFLogxK

    U2 - 10.1016/0304-3940(96)12565-9

    DO - 10.1016/0304-3940(96)12565-9

    M3 - Article

    VL - 208

    SP - 129

    EP - 132

    JO - Neuroscience Letters

    JF - Neuroscience Letters

    SN - 0304-3940

    IS - 2

    ER -