Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata

Youichi Nakao, Shizuka Kawatsu, Chikane Okamoto, Masaaki Okamoto, Yoshitsugu Matsumoto, Shigeki Matsunaga, Rob W M Van Soest, Nobuhiro Fusetani

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    Three lipopeptides, ciliatamides A-C (1-3), were isolated from the deep-sea sponge Aaptos ciliata, and their structures were elucidated on the basis of spectroscopic and chemical methods. Ciliatamides A (1) and B (2) were found to be antileishmanial, while 2 also exhibited marginal cytotoxicity to HeLa cells.

    Original languageEnglish
    Pages (from-to)469-472
    Number of pages4
    JournalJournal of Natural Products
    Volume71
    Issue number3
    DOIs
    Publication statusPublished - 2008 Mar

    Fingerprint

    Aaptos
    Ciliophora
    lipopeptides
    Lipopeptides
    Porifera
    Oceans and Seas
    cytotoxicity
    Cytotoxicity
    HeLa Cells
    cells
    methodology
    ciliatamide C
    ciliatamide A

    ASJC Scopus subject areas

    • Plant Science
    • Chemistry (miscellaneous)
    • Drug Discovery
    • Organic Chemistry
    • Pharmacology

    Cite this

    Nakao, Y., Kawatsu, S., Okamoto, C., Okamoto, M., Matsumoto, Y., Matsunaga, S., ... Fusetani, N. (2008). Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata. Journal of Natural Products, 71(3), 469-472. https://doi.org/10.1021/np8000317

    Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata. / Nakao, Youichi; Kawatsu, Shizuka; Okamoto, Chikane; Okamoto, Masaaki; Matsumoto, Yoshitsugu; Matsunaga, Shigeki; Van Soest, Rob W M; Fusetani, Nobuhiro.

    In: Journal of Natural Products, Vol. 71, No. 3, 03.2008, p. 469-472.

    Research output: Contribution to journalArticle

    Nakao, Y, Kawatsu, S, Okamoto, C, Okamoto, M, Matsumoto, Y, Matsunaga, S, Van Soest, RWM & Fusetani, N 2008, 'Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata', Journal of Natural Products, vol. 71, no. 3, pp. 469-472. https://doi.org/10.1021/np8000317
    Nakao, Youichi ; Kawatsu, Shizuka ; Okamoto, Chikane ; Okamoto, Masaaki ; Matsumoto, Yoshitsugu ; Matsunaga, Shigeki ; Van Soest, Rob W M ; Fusetani, Nobuhiro. / Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata. In: Journal of Natural Products. 2008 ; Vol. 71, No. 3. pp. 469-472.
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    AU - Van Soest, Rob W M

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