Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata

Yoichi Nakao, Shizuka Kawatsu, Chikane Okamoto, Masaaki Okamoto, Yoshitsugu Matsumoto, Shigeki Matsunaga, Rob W.M. Van Soest, Nobuhiro Fusetani

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21 Citations (Scopus)

Abstract

Three lipopeptides, ciliatamides A-C (1-3), were isolated from the deep-sea sponge Aaptos ciliata, and their structures were elucidated on the basis of spectroscopic and chemical methods. Ciliatamides A (1) and B (2) were found to be antileishmanial, while 2 also exhibited marginal cytotoxicity to HeLa cells.

Original languageEnglish
Pages (from-to)469-472
Number of pages4
JournalJournal of Natural Products
Volume71
Issue number3
DOIs
Publication statusPublished - 2008 Mar 1

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Nakao, Y., Kawatsu, S., Okamoto, C., Okamoto, M., Matsumoto, Y., Matsunaga, S., Van Soest, R. W. M., & Fusetani, N. (2008). Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata. Journal of Natural Products, 71(3), 469-472. https://doi.org/10.1021/np8000317