Circadian rhythm study from anticipatory behavior to drug treatment

    Research output: Contribution to journalArticle

    Abstract

    Precise, rhythmic, daily change of the internal milieu is a conspicuous feature of all living organisms. It affects temporal patterns of all kinds of behaviors during a day and deeply influences both the social structure and daily life of individual human beings. These daily variations arise from the internal circadian mechanisms. Three functions of the endogenous clock are discriminated as rhythm generation, entrainment to light-dark cycle and output from the clock. The endogenous clock is localized in the suprachiasmatic nucleus (SCN) in mammals. Recent papers demonstrated strong expression of clock genes such as Per1, Per2 and Per3 in the SCN. Circadian oscillation is basically regulated by the transcription/translation feedback system of the Per gene in mammals. As serotonin/antidepressant and GABA/benzodiazepine drugs affect the light and non-light-induced entrainment, these drugs can regulate the circadian oscillation of clock genes and environmental stimuli-induced change of Per gene expression in the SCN. There are two main stimuli that entrain circadian rhythm, the light-dark cycle (LD) and restricted feeding. Light resets the circadian clock with induction of Per1 and Per2 gene in the SCN, the locus of a main oscillator. Mice were allowed access to food for 4 h during daytime (7 h in advance of feeding time) under LD or constant darkness. The peaks of mPer1 and mPer2 mRNA in the cerebral cortex and liver were advanced 6-12 h after 6 days of RF, whereas those in SCN were unaffected. The increase of mPer expression by RF treatment was observed in SCN-lesioned mice. The present results suggest that RF strongly entrained the expression of mPer and clock-controlled genes in the cerebral cortex and liver without affecting light-dependent SCN clock function.

    Original languageEnglish
    Pages (from-to)251-258
    Number of pages8
    JournalJapanese Journal of Neuropsychopharmacology
    Volume25
    Issue number5
    Publication statusPublished - 2005 Oct

    Fingerprint

    Suprachiasmatic Nucleus
    Circadian Rhythm
    Pharmaceutical Preparations
    Photoperiod
    Circadian Clocks
    Light
    Cerebral Cortex
    Genes
    Mammals
    Gene Expression
    Liver
    Darkness
    Benzodiazepines
    gamma-Aminobutyric Acid
    Antidepressive Agents
    Serotonin
    Food
    Messenger RNA

    Keywords

    • Anticipation
    • Circadian
    • Clock gene
    • CNS drug
    • Suprachiasmatic

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Pharmacology (medical)
    • Pharmacology, Toxicology and Pharmaceutics(all)

    Cite this

    Circadian rhythm study from anticipatory behavior to drug treatment. / Shibata, Shigenobu.

    In: Japanese Journal of Neuropsychopharmacology, Vol. 25, No. 5, 10.2005, p. 251-258.

    Research output: Contribution to journalArticle

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