Circulating endogenous thrombopoietin, interleukin-3, interleukin-6 and interleukin-11 levels in patients undergoing allogeneic bone marrow transplantation

Akaru Ishida, Yoshitaka Miyakawa, Ryuji Tanosaki, Masatoshi Wakui, Hironori Ueno, Reiko Watanabe, Norihiro Awaya, Tomoyuki Tahara, Takashi Kato, Hiroshi Miyazaki, Atsushi Oda, Masahiro Kizaki, Shinichiro Okamoto, Yasuo Ikeda

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To elucidate the physiologic role of thrombopoietin (TPO) for hematologic reconstitution following allogeneic bone marrow transplantation (BMT), serum TPO levels as well as interleukin-3 (IL-3), IL-6 and IL-11 were serially measured in 55 samples from 3 patients who underwent allogeneic BMT using an enzyme-linked immunosorbent assay (ELISA). The TPO level was higher in the serum taken during marrow aplasia than in the pretransplant serum. The serum TPO levels and platelet counts showed a strong inverse relationship in all patients examined. We also sequentially measured endogenous serum TPO levels before and within 36 h after platelet transfusions. Endogenous serum TPO levels were inversely correlated with platelet mass following platelet transfusions. Serum levels of IL-3 had no apparent correlation with platelet counts and serum levels of IL-11 remained below the detection levels (31.3 pg/ml) in all samples. Serum levels of IL-6 were high during myeloaplasia and more upregulated in the febrile period. These findings support the view that TPO is the central regulator for megakaryopoiesis in vivo and the rationale for its clinical use after allogeneic BMT.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalInternational Journal of Hematology
Volume65
Issue number1
Publication statusPublished - 1996 Dec 1
Externally publishedYes

Keywords

  • Allogeneic bone marrow transplantation
  • Interleukin-11
  • Interleukin-3
  • Interleukin-6
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Circulating endogenous thrombopoietin, interleukin-3, interleukin-6 and interleukin-11 levels in patients undergoing allogeneic bone marrow transplantation'. Together they form a unique fingerprint.

  • Cite this

    Ishida, A., Miyakawa, Y., Tanosaki, R., Wakui, M., Ueno, H., Watanabe, R., Awaya, N., Tahara, T., Kato, T., Miyazaki, H., Oda, A., Kizaki, M., Okamoto, S., & Ikeda, Y. (1996). Circulating endogenous thrombopoietin, interleukin-3, interleukin-6 and interleukin-11 levels in patients undergoing allogeneic bone marrow transplantation. International Journal of Hematology, 65(1), 61-69.