Circulating thrombopoietin level in chronic immune thrombocytopenic purpura

Satoru Kosugi; Yoshiyuki Kurata; Yoshiaki Tomiyama; Tomoyuki Tahara; Takashi Kato; Seiji Tadokoro; Masamichi Shiraga; Shigenori Honda; Yuzuru Kanakura; Yuji Matsuzawa

doi:10.1046/j.1365-2141.1996.d01-1702.x

Circulating thrombopoietin level in chronic immune thrombocytopenic purpura

Satoru Kosugi, Yoshiyuki Kurata^*, Yoshiaki Tomiyama, Tomoyuki Tahara, Takashi Kato, Seiji Tadokoro, Masamichi Shiraga, Shigenori Honda, Yuzuru Kanakura, Yuji Matsuzawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

174 Citations (Scopus)

Abstract

The circulating thrombopoietin (TPO) level in 43 patients with chronic immune thrombocytopenic purpura (ITP) was examined by an ELISA system, The TPO level (mean ± SD) in ITP patients was mildly elevated (186 ± 1.17 fmol/ml) compared to that in normal subjects (0.76 ± 0.21), and was within the normal range in 30% of ITP patients. In contrast, the TPO level in patients with aplastic anaemia was very high, 12.35 ± 642 fmol/ml. There was no correlation between TPO level and platelet count in ITP patients. Splenectomy was performed in two ITP patients, after which platelet counts increased to normal levels and TPO levels showed a transient increase. These data suggest that reactive TPO production against thrombocytopenia in ITP is small when compared to that in aplastic anaemia. Relative endogenous TPO deficiency may play some role in the pathophysiology of thrombocytopenia in ITP patients.

Original language	English
Pages (from-to)	704-706
Number of pages	3
Journal	British Journal of Haematology
Volume	93
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2141.1996.d01-1702.x
Publication status	Published - 1996 Jan 1
Externally published	Yes

Keywords

Aplastic anaemia
ITP
Thrombopoietin

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.1996.d01-1702.x

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title = "Circulating thrombopoietin level in chronic immune thrombocytopenic purpura",

abstract = "The circulating thrombopoietin (TPO) level in 43 patients with chronic immune thrombocytopenic purpura (ITP) was examined by an ELISA system, The TPO level (mean ± SD) in ITP patients was mildly elevated (186 ± 1.17 fmol/ml) compared to that in normal subjects (0.76 ± 0.21), and was within the normal range in 30% of ITP patients. In contrast, the TPO level in patients with aplastic anaemia was very high, 12.35 ± 642 fmol/ml. There was no correlation between TPO level and platelet count in ITP patients. Splenectomy was performed in two ITP patients, after which platelet counts increased to normal levels and TPO levels showed a transient increase. These data suggest that reactive TPO production against thrombocytopenia in ITP is small when compared to that in aplastic anaemia. Relative endogenous TPO deficiency may play some role in the pathophysiology of thrombocytopenia in ITP patients.",

keywords = "Aplastic anaemia, ITP, Thrombopoietin",

author = "Satoru Kosugi and Yoshiyuki Kurata and Yoshiaki Tomiyama and Tomoyuki Tahara and Takashi Kato and Seiji Tadokoro and Masamichi Shiraga and Shigenori Honda and Yuzuru Kanakura and Yuji Matsuzawa",

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doi = "10.1046/j.1365-2141.1996.d01-1702.x",

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AU - Kosugi, Satoru

AU - Kurata, Yoshiyuki

AU - Tomiyama, Yoshiaki

AU - Tahara, Tomoyuki

AU - Kato, Takashi

AU - Tadokoro, Seiji

AU - Shiraga, Masamichi

AU - Honda, Shigenori

AU - Kanakura, Yuzuru

AU - Matsuzawa, Yuji

PY - 1996/1/1

Y1 - 1996/1/1

N2 - The circulating thrombopoietin (TPO) level in 43 patients with chronic immune thrombocytopenic purpura (ITP) was examined by an ELISA system, The TPO level (mean ± SD) in ITP patients was mildly elevated (186 ± 1.17 fmol/ml) compared to that in normal subjects (0.76 ± 0.21), and was within the normal range in 30% of ITP patients. In contrast, the TPO level in patients with aplastic anaemia was very high, 12.35 ± 642 fmol/ml. There was no correlation between TPO level and platelet count in ITP patients. Splenectomy was performed in two ITP patients, after which platelet counts increased to normal levels and TPO levels showed a transient increase. These data suggest that reactive TPO production against thrombocytopenia in ITP is small when compared to that in aplastic anaemia. Relative endogenous TPO deficiency may play some role in the pathophysiology of thrombocytopenia in ITP patients.

AB - The circulating thrombopoietin (TPO) level in 43 patients with chronic immune thrombocytopenic purpura (ITP) was examined by an ELISA system, The TPO level (mean ± SD) in ITP patients was mildly elevated (186 ± 1.17 fmol/ml) compared to that in normal subjects (0.76 ± 0.21), and was within the normal range in 30% of ITP patients. In contrast, the TPO level in patients with aplastic anaemia was very high, 12.35 ± 642 fmol/ml. There was no correlation between TPO level and platelet count in ITP patients. Splenectomy was performed in two ITP patients, after which platelet counts increased to normal levels and TPO levels showed a transient increase. These data suggest that reactive TPO production against thrombocytopenia in ITP is small when compared to that in aplastic anaemia. Relative endogenous TPO deficiency may play some role in the pathophysiology of thrombocytopenia in ITP patients.

KW - Aplastic anaemia

KW - ITP

KW - Thrombopoietin

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Circulating thrombopoietin level in chronic immune thrombocytopenic purpura

Abstract

Keywords

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