Circulating thrombopoietin level in chronic immune thrombocytopenic purpura

Satoru Kosugi, Yoshiyuki Kurata, Yoshiaki Tomiyama, Tomoyuki Tahara, Takashi Kato, Seiji Tadokoro, Masamichi Shiraga, Shigenori Honda, Yuzuru Kanakura, Yuji Matsuzawa

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Abstract

The circulating thrombopoietin (TPO) level in 43 patients with chronic immune thrombocytopenic purpura (ITP) was examined by an ELISA system, The TPO level (mean ± SD) in ITP patients was mildly elevated (186 ± 1.17 fmol/ml) compared to that in normal subjects (0.76 ± 0.21), and was within the normal range in 30% of ITP patients. In contrast, the TPO level in patients with aplastic anaemia was very high, 12.35 ± 642 fmol/ml. There was no correlation between TPO level and platelet count in ITP patients. Splenectomy was performed in two ITP patients, after which platelet counts increased to normal levels and TPO levels showed a transient increase. These data suggest that reactive TPO production against thrombocytopenia in ITP is small when compared to that in aplastic anaemia. Relative endogenous TPO deficiency may play some role in the pathophysiology of thrombocytopenia in ITP patients.

Original languageEnglish
Pages (from-to)704-706
Number of pages3
JournalBritish Journal of Haematology
Volume93
Issue number3
DOIs
Publication statusPublished - 1996 Jan 1

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Keywords

  • Aplastic anaemia
  • ITP
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology

Cite this

Kosugi, S., Kurata, Y., Tomiyama, Y., Tahara, T., Kato, T., Tadokoro, S., Shiraga, M., Honda, S., Kanakura, Y., & Matsuzawa, Y. (1996). Circulating thrombopoietin level in chronic immune thrombocytopenic purpura. British Journal of Haematology, 93(3), 704-706. https://doi.org/10.1046/j.1365-2141.1996.d01-1702.x