Clearance and tissue distribution of functionalized polymeric liposomes from the blood stream of rats

Yoh Ichi Matsushita, Kiyoshi Eshima, Takashi Shindo, Yoshio Yamamoto, Etsuo Hasegawa, Hiroyuki Nishide, Eishun Tsuchida*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Polymeric liposomes containing a synthetic porphinato-iron-imidazole complex (hemoglobin or red blood cell model) were labeled by introducing 1,2-di[1-14C]palmitoyl-sn-glycero-3-phosphocholine into their polymerized bilayers. After intravenous injection into rats, their clearance from a blood stream was measured. The apparent half-life time (50% disappearance time) was about 14 ± 2 h. Their tissue distribution was determined with time by whole autoradiographic measurement.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalBBA - Biomembranes
Volume901
Issue number1
DOIs
Publication statusPublished - 1987 Jul 10

Keywords

  • Hemoglobin model
  • Lipid label
  • Liposome clearance
  • Oxygen carrier
  • Polymeric liposome
  • Tissue distribution

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Medicine(all)

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