Clearance and tissue distribution of functionalized polymeric liposomes from the blood stream of rats

Yoh Ichi Matsushita, Kiyoshi Eshima, Takashi Shindo, Yoshio Yamamoto, Etsuo Hasegawa, Hiroyuki Nishide, Eishun Tsuchida

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Polymeric liposomes containing a synthetic porphinato-iron-imidazole complex (hemoglobin or red blood cell model) were labeled by introducing 1,2-di[1-14C]palmitoyl-sn-glycero-3-phosphocholine into their polymerized bilayers. After intravenous injection into rats, their clearance from a blood stream was measured. The apparent half-life time (50% disappearance time) was about 14 ± 2 h. Their tissue distribution was determined with time by whole autoradiographic measurement.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalBBA - Biomembranes
Volume901
Issue number1
DOIs
Publication statusPublished - 1987 Jul 10

Keywords

  • Hemoglobin model
  • Lipid label
  • Liposome clearance
  • Oxygen carrier
  • Polymeric liposome
  • Tissue distribution

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Clearance and tissue distribution of functionalized polymeric liposomes from the blood stream of rats'. Together they form a unique fingerprint.

  • Cite this

    Matsushita, Y. I., Eshima, K., Shindo, T., Yamamoto, Y., Hasegawa, E., Nishide, H., & Tsuchida, E. (1987). Clearance and tissue distribution of functionalized polymeric liposomes from the blood stream of rats. BBA - Biomembranes, 901(1), 166-171. https://doi.org/10.1016/0005-2736(87)90269-0