Clinical and psychological aspects of restless legs syndrome in uremic patients on hemodialysis

Jiro Takaki, Tadahiro Nishi, Masaomi Nangaku, Hiromi Shimoyama, Toshio Inada, Norimasa Matsuyama, Hiroaki Kumano, Tomifusa Kuboki

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Background: The pathogenesis of restless legs syndrome (RLS) is still unclear. The purpose of this study is to determine relationships of the presence of RLS in uremic patients regularly undergoing hemodialysis (HD) with demographic, clinical, and psychological factors. Methods: In 490 uremic patients on HD therapy in Japan, RLS was diagnosed based on diagnostic criteria established by the International Restless Legs Syndrome Study Group. Data were compared between patients with and without RLS. Results: There were univariately significant (P < 0.05) differences in serum phosphorus levels, anxiety levels determined using the Hospital Anxiety and Depression Scale, and degrees of emotion-oriented and avoidance-oriented coping determined using the Coping Inventory for Stressful Situations. In multivariate analyses, low hemoglobin levels, high serum phosphorus levels, high anxiety levels, and a great degree of emotion-oriented coping were independently related to the presence of RLS in uremic patients on HD therapy, with statistical significance (P < 0.05). Conclusion: Hyperphosphatemia, anxiety, and a great degree of emotion-oriented coping with stress were independently related to the presence of RLS in uremic patients on HD therapy. The pathogenesis of RLS seems to involve more than one mechanism, which leads to restless legs as the final common pathway. These findings may provide new clues to the pathogenesis of RLS.

Original languageEnglish
Pages (from-to)833-839
Number of pages7
JournalAmerican Journal of Kidney Diseases
Volume41
Issue number4
DOIs
Publication statusPublished - 2003 Apr 1

Keywords

  • Anxiety
  • Coping
  • Hemodialysis (HD)
  • Hemoglobin
  • Phosphorus
  • Restless legs syndrome (RLS)

ASJC Scopus subject areas

  • Nephrology

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