Clinical evaluation of intraoperative radiotherapy using photon radiosurgery system for brain tumors

O. Kubo, Y. Muragaki, H. Iseki, K. Takakura

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    The photon radiosurgery system is a miniature X-ray generator that can be placed stereotactically and intraoperatively into intracranial tumors to deliver a single fraction of high-dose interstitial irradiation. This battery-powered device produces low energy X-ray photons in a spherical and symmetrical pattern at the probe tip. Dose rates of up to 200 cGy/Mim are possible, allowing for the administration of 15 Gy to a lesion 3 cm in diameter in less than 1 hr. Background exposure is minimal, and no special shielding of the patient or health care personnel is required. Thirty-nine patients with brain tumor were treated in this method. There were no adverse effects. During the follow-up period of 1-30 months, 3 cases with 5 metastatic brain tumors died about 8 months after this treatment. Five recurrent cases of 21 malignant gliomas died about 4 months after treatment. Interstitial radiotherapy using photon the radiosurgery system promises to be a useful treatment for brain tumors.

    Original languageEnglish
    Pages (from-to)1348-1351
    Number of pages4
    JournalGan to kagaku ryoho. Cancer & chemotherapy
    Volume25
    Issue number9
    Publication statusPublished - 1998 Jul

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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