Clinical evaluation of intraoperative radiotherapy using photon radiosurgery system for brain tumors

O. Kubo, Y. Muragaki, Hiroshi Iseki, K. Takakura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The photon radiosurgery system is a miniature X-ray generator that can be placed stereotactically and intraoperatively into intracranial tumors to deliver a single fraction of high-dose interstitial irradiation. This battery-powered device produces low energy X-ray photons in a spherical and symmetrical pattern at the probe tip. Dose rates of up to 200 cGy/Mim are possible, allowing for the administration of 15 Gy to a lesion 3 cm in diameter in less than 1 hr. Background exposure is minimal, and no special shielding of the patient or health care personnel is required. Thirty-nine patients with brain tumor were treated in this method. There were no adverse effects. During the follow-up period of 1-30 months, 3 cases with 5 metastatic brain tumors died about 8 months after this treatment. Five recurrent cases of 21 malignant gliomas died about 4 months after treatment. Interstitial radiotherapy using photon the radiosurgery system promises to be a useful treatment for brain tumors.

Original languageEnglish
Pages (from-to)1348-1351
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume25
Issue number9
Publication statusPublished - 1998 Jul
Externally publishedYes

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Radiosurgery
Photons
Brain Neoplasms
Radiotherapy
X-Rays
Brachytherapy
Glioma
Health Personnel
Patient Care
Therapeutics
Delivery of Health Care
Equipment and Supplies
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

Cite this

Clinical evaluation of intraoperative radiotherapy using photon radiosurgery system for brain tumors. / Kubo, O.; Muragaki, Y.; Iseki, Hiroshi; Takakura, K.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 25, No. 9, 07.1998, p. 1348-1351.

Research output: Contribution to journalArticle

Kubo, O. ; Muragaki, Y. ; Iseki, Hiroshi ; Takakura, K. / Clinical evaluation of intraoperative radiotherapy using photon radiosurgery system for brain tumors. In: Gan to kagaku ryoho. Cancer & chemotherapy. 1998 ; Vol. 25, No. 9. pp. 1348-1351.
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