Clinical measurement of tumor fluorescence using a new diagnostic system with hematoporphyrin derivative, laser photoradiation, and a spectroscope

Harubumi Kato, Jutaro Ono, Chimori Konaka, Norihiko Kawate, Kazuo Yoneyama, Komei Kinoshita, Katsuaki Nishimiya, Harumasa Sakai, Masayuki Noguchi, Takahisa Tomono, Yoshihiro Hayata, Katsuo Aizawa, Satoru Kawasaki, Yasuaki Tokuda

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Hematoporphyrin derivative (HPD) is retained by malignant tumors and emits fluorescence with peaks of 630 and 690 nm wavelength when HPD is exposed to light. It is therefore theoretically possible to make a diagnosis of malignant tumors by detecting the fluorescence of HPD. The authors developed a spectroscope system compatible with fiberoptic endoscopes to analyze the shape of the fluorescence light spectrum. We could clearly recognize the HPD‐specific fluorescence in human cancer foci. This system can be applied to the measurement of the relative amount of HPD absorbed in superficial tumor tissue before the photodynamic therapy. This might suggest the extent of tumor. The clinical diagnostic applications of this system are described in this study.

Original languageEnglish
Pages (from-to)49-58
Number of pages10
JournalLasers in Surgery and Medicine
Volume4
Issue number1
DOIs
Publication statusPublished - 1984
Externally publishedYes

Keywords

  • autofluorescence
  • bladder cancer
  • diagnostic system
  • hematoporphyrin derivative
  • krypton ion laser
  • lung cancer
  • photofrin II
  • skin cancer
  • spectroscope
  • stomach cancer

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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  • Cite this

    Kato, H., Ono, J., Konaka, C., Kawate, N., Yoneyama, K., Kinoshita, K., Nishimiya, K., Sakai, H., Noguchi, M., Tomono, T., Hayata, Y., Aizawa, K., Kawasaki, S., & Tokuda, Y. (1984). Clinical measurement of tumor fluorescence using a new diagnostic system with hematoporphyrin derivative, laser photoradiation, and a spectroscope. Lasers in Surgery and Medicine, 4(1), 49-58. https://doi.org/10.1002/lsm.1900040107