Close linkage between calcium/calmodulin kinase II α/β and NMDA-2A receptors in the lateral amygdala and significance for retrieval of auditory fear conditioning

Takahiro Moriya, Yasuko Kouzu, Shigenobu Shibata, Hiroshi Kadotani, Kohji Fukunaga, Eishichi Miyamoto, Tohru Yoshioka

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    The general mechanism underlying memory and learning is an area under intense investigation and debate, yet this mechanism remains elusive. Auditory fear conditioning (when a tone is paired with a foot shock) is a simple associative form of learning for which many mechanistic details are known. Lesions of the lateral/basolateral nuclei of the amygdala result in the selective impairment of fear conditioning, indicating that this is a key region for this type of learning. Fear conditioning induces a lasting synaptic potentiation in the lateral nuclei of the amygdala. In addition, recent results from several laboratories suggest that N-methyl-D-aspartate (NMDA) receptor activation in the amygdala is required for the acquisition and expression of cue-conditioned fear responses using several kinds of antagonists. Little is known, however, about the signal transduction pathway and molecular substrate underlying fear conditioning. Here we use NMDA receptor-deficient mice to demonstrate that calmodulin-dependent kinase II, CaMKIIβ, and CaMKIIα activation involves the NR2A subunit in the lateral/basolateral amygdala during memory retrieval following auditory fear conditioning. These results suggest that auditory fear conditioning involves a close linkage between NMDA2A receptors and the CaMKII cascade.

    Original languageEnglish
    Pages (from-to)3307-3314
    Number of pages8
    JournalEuropean Journal of Neuroscience
    Volume12
    Issue number9
    DOIs
    Publication statusPublished - 2000

    Fingerprint

    Calcium-Calmodulin-Dependent Protein Kinases
    Amygdala
    N-Methyl-D-Aspartate Receptors
    Fear
    Calcium
    Calcium-Calmodulin-Dependent Protein Kinase Type 2
    Learning
    Conditioning (Psychology)
    Cues
    Foot
    Shock
    Signal Transduction
    Basolateral Nuclear Complex

    Keywords

    • Associated learning
    • CaMKII
    • Glutamate
    • Mutant mice

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Close linkage between calcium/calmodulin kinase II α/β and NMDA-2A receptors in the lateral amygdala and significance for retrieval of auditory fear conditioning. / Moriya, Takahiro; Kouzu, Yasuko; Shibata, Shigenobu; Kadotani, Hiroshi; Fukunaga, Kohji; Miyamoto, Eishichi; Yoshioka, Tohru.

    In: European Journal of Neuroscience, Vol. 12, No. 9, 2000, p. 3307-3314.

    Research output: Contribution to journalArticle

    Moriya, Takahiro ; Kouzu, Yasuko ; Shibata, Shigenobu ; Kadotani, Hiroshi ; Fukunaga, Kohji ; Miyamoto, Eishichi ; Yoshioka, Tohru. / Close linkage between calcium/calmodulin kinase II α/β and NMDA-2A receptors in the lateral amygdala and significance for retrieval of auditory fear conditioning. In: European Journal of Neuroscience. 2000 ; Vol. 12, No. 9. pp. 3307-3314.
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