Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices

Shinpei Yoshimura, Yasumasa Okamoto, Miki Matsunaga, Keiichi Onoda, Go Okada, Yoshihiko Kunisato, Atsuo Yoshino, Kazutaka Ueda, Shinichi Suzuki, Shigeto Yamawaki

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Background Depression is characterized by negative self-cognition. Our previous study (Yoshimura et al. 2014) revealed changes in brain activity after cognitive behavioral therapy (CBT) for depression, but changes in functional connectivity were not assessed. Method This study included 29 depressive patients and 15 healthy control participants. Functional Magnetic Resonance Imaging was used to investigate possible CBT-related functional connectivity changes associated with negative emotional self-referential processing. Depressed and healthy participants (overlapping with our previous study, Yoshimura et al. 2014) were included. We defined a seed region (medial prefrontal cortex) and coupled region (ACC) based on our previous study, and we examined changes in MPFC-ACC functional connectivity from pretreatment to posttreatment. Results CBT was associated with reduced functional connectivity between the MPFC and ACC. Symptom change with CBT was positively correlated with change in MPFC-ACC functional connectivity. Limitations Patients received pharmacotherapy including antidepressant. The present sample size was quite small and more study is needed. Statistical threshold in fMRI analysis was relatively liberal. Conclusions CBT for depression may disrupt MPFC-ACC connectivity, with associated improvements in depressive symptoms and dysfunctional cognition.

    Original languageEnglish
    Pages (from-to)610-614
    Number of pages5
    JournalJournal of Affective Disorders
    Volume208
    DOIs
    Publication statusPublished - 2017 Jan 15

    Fingerprint

    Gyrus Cinguli
    Cognitive Therapy
    Depression
    Cognition
    Healthy Volunteers
    Magnetic Resonance Imaging
    Prefrontal Cortex
    Sample Size
    Antidepressive Agents
    Seeds
    Drug Therapy
    Brain

    Keywords

    • Cognitive behavioral therapy
    • Depression
    • FMRI
    • Functional connectivity
    • Self

    ASJC Scopus subject areas

    • Clinical Psychology
    • Psychiatry and Mental health

    Cite this

    Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices. / Yoshimura, Shinpei; Okamoto, Yasumasa; Matsunaga, Miki; Onoda, Keiichi; Okada, Go; Kunisato, Yoshihiko; Yoshino, Atsuo; Ueda, Kazutaka; Suzuki, Shinichi; Yamawaki, Shigeto.

    In: Journal of Affective Disorders, Vol. 208, 15.01.2017, p. 610-614.

    Research output: Contribution to journalArticle

    Yoshimura, S, Okamoto, Y, Matsunaga, M, Onoda, K, Okada, G, Kunisato, Y, Yoshino, A, Ueda, K, Suzuki, S & Yamawaki, S 2017, 'Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices', Journal of Affective Disorders, vol. 208, pp. 610-614. https://doi.org/10.1016/j.jad.2016.10.017
    Yoshimura, Shinpei ; Okamoto, Yasumasa ; Matsunaga, Miki ; Onoda, Keiichi ; Okada, Go ; Kunisato, Yoshihiko ; Yoshino, Atsuo ; Ueda, Kazutaka ; Suzuki, Shinichi ; Yamawaki, Shigeto. / Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices. In: Journal of Affective Disorders. 2017 ; Vol. 208. pp. 610-614.
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    abstract = "Background Depression is characterized by negative self-cognition. Our previous study (Yoshimura et al. 2014) revealed changes in brain activity after cognitive behavioral therapy (CBT) for depression, but changes in functional connectivity were not assessed. Method This study included 29 depressive patients and 15 healthy control participants. Functional Magnetic Resonance Imaging was used to investigate possible CBT-related functional connectivity changes associated with negative emotional self-referential processing. Depressed and healthy participants (overlapping with our previous study, Yoshimura et al. 2014) were included. We defined a seed region (medial prefrontal cortex) and coupled region (ACC) based on our previous study, and we examined changes in MPFC-ACC functional connectivity from pretreatment to posttreatment. Results CBT was associated with reduced functional connectivity between the MPFC and ACC. Symptom change with CBT was positively correlated with change in MPFC-ACC functional connectivity. Limitations Patients received pharmacotherapy including antidepressant. The present sample size was quite small and more study is needed. Statistical threshold in fMRI analysis was relatively liberal. Conclusions CBT for depression may disrupt MPFC-ACC connectivity, with associated improvements in depressive symptoms and dysfunctional cognition.",
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    AU - Okamoto, Yasumasa

    AU - Matsunaga, Miki

    AU - Onoda, Keiichi

    AU - Okada, Go

    AU - Kunisato, Yoshihiko

    AU - Yoshino, Atsuo

    AU - Ueda, Kazutaka

    AU - Suzuki, Shinichi

    AU - Yamawaki, Shigeto

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    N2 - Background Depression is characterized by negative self-cognition. Our previous study (Yoshimura et al. 2014) revealed changes in brain activity after cognitive behavioral therapy (CBT) for depression, but changes in functional connectivity were not assessed. Method This study included 29 depressive patients and 15 healthy control participants. Functional Magnetic Resonance Imaging was used to investigate possible CBT-related functional connectivity changes associated with negative emotional self-referential processing. Depressed and healthy participants (overlapping with our previous study, Yoshimura et al. 2014) were included. We defined a seed region (medial prefrontal cortex) and coupled region (ACC) based on our previous study, and we examined changes in MPFC-ACC functional connectivity from pretreatment to posttreatment. Results CBT was associated with reduced functional connectivity between the MPFC and ACC. Symptom change with CBT was positively correlated with change in MPFC-ACC functional connectivity. Limitations Patients received pharmacotherapy including antidepressant. The present sample size was quite small and more study is needed. Statistical threshold in fMRI analysis was relatively liberal. Conclusions CBT for depression may disrupt MPFC-ACC connectivity, with associated improvements in depressive symptoms and dysfunctional cognition.

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