Cognitive behavioral therapy for depression changes medial prefrontal and ventral anterior cingulate cortex activity associated with self-referential processing

Shinpei Yoshimura, Yasumasa Okamoto, Keiichi Onoda, Miki Matsunaga, Go Okada, Yoshihiko Kunisato, Atsuo Yoshino, Kazutaka Ueda, Shinichi Suzuki, Shigeto Yamawaki

    Research output: Contribution to journalArticle

    90 Citations (Scopus)

    Abstract

    Cognitive behavioral therapy (CBT), an effective treatment for depression, targets self-referential processing of emotional stimuli. We examined the effects of CBT on brain functioning during self-referential processing in depressive patients using functional magnetic resonance imaging (fMRI). Depressive patients (n = 23) and healthy participants (n = 15) underwent fMRI scans during a self-referential task using emotional trait words. The depressive patients had fMRI scans before and after completing a total of 12 weekly sessions of group CBT for depression, whereas the healthy participants underwent fMRI scans 12 weeks apart with no intervention. Before undergoing CBT, the depressive patients showed hyperactivity in the medial prefrontal cortex (MPFC) during self-referential processing of negative words. Following CBT, MPFC and ventral anterior cingulate cortex (vACC) activity during self-referential processing among depressive patients was increased for positive stimuli, whereas it was decreased for negative stimuli. Improvements in depressive symptoms were negatively correlated with vACC activity during self-referential processing of negative stimuli. These results suggest that CBT-related improvements in depressive symptoms are associated with changes in MPFC and vACC activation during self-referential processing of emotional stimuli.

    Original languageEnglish
    Article numbernst009
    Pages (from-to)487-493
    Number of pages7
    JournalSocial Cognitive and Affective Neuroscience
    Volume9
    Issue number4
    DOIs
    Publication statusPublished - 2014

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    Gyrus Cinguli
    Cognitive Therapy
    Depression
    Prefrontal Cortex
    Magnetic Resonance Imaging
    Healthy Volunteers
    Word Processing
    Brain

    Keywords

    • Cognitive behavioral therapy
    • Depression
    • Emotion
    • fMRI
    • Self-referential processing

    ASJC Scopus subject areas

    • Cognitive Neuroscience
    • Experimental and Cognitive Psychology
    • Medicine(all)

    Cite this

    Cognitive behavioral therapy for depression changes medial prefrontal and ventral anterior cingulate cortex activity associated with self-referential processing. / Yoshimura, Shinpei; Okamoto, Yasumasa; Onoda, Keiichi; Matsunaga, Miki; Okada, Go; Kunisato, Yoshihiko; Yoshino, Atsuo; Ueda, Kazutaka; Suzuki, Shinichi; Yamawaki, Shigeto.

    In: Social Cognitive and Affective Neuroscience, Vol. 9, No. 4, nst009, 2014, p. 487-493.

    Research output: Contribution to journalArticle

    Yoshimura, Shinpei ; Okamoto, Yasumasa ; Onoda, Keiichi ; Matsunaga, Miki ; Okada, Go ; Kunisato, Yoshihiko ; Yoshino, Atsuo ; Ueda, Kazutaka ; Suzuki, Shinichi ; Yamawaki, Shigeto. / Cognitive behavioral therapy for depression changes medial prefrontal and ventral anterior cingulate cortex activity associated with self-referential processing. In: Social Cognitive and Affective Neuroscience. 2014 ; Vol. 9, No. 4. pp. 487-493.
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