Cold exposure and/or fasting modulate the relationship between sleep and body temperature rhythms in mice

Nobuo Sato, Shuri Marui, Makoto Ozaki, Kei Nagashima

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    We assessed the relationship between core temperature (T<inf>c</inf>) and sleep rhythms in mice, and examined the effects of ambient temperature and fasting. T<inf>c</inf>, electroencephalograms (EEG), electromyograms (EMG), and spontaneous activity in male ICR mice (n=9) were measured by telemetry for 3days under a 12:12h dark-light cycle. Mice were fed or fasted at an ambient temperature (T<inf>a</inf>) of 27°C or 20°C for the final 30h of the experiment. The vigilance state was categorized into a wake state, rapid-eye movement (REM) sleep, and non-REM (NREM) sleep, and the total sleep time (TST) was assessed. Relationships between T<inf>c</inf> and TST, NREM periods, and REM sleep were estimated using Pearson's correlation coefficient. During cold exposure, T<inf>c</inf> decreased during the dark and light phases, and TST and the periods of NREM and REM sleep decreased during the dark phase. Throughout the fasting period, T<inf>c</inf> also decreased during the dark and light phases. Furthermore, the decrease in T<inf>c</inf> was augmented when fasting and cold were combined. TST and NREM sleep periods decreased in the light and dark phases, respectively, whereas REM sleep periods decreased in both phases. Negative linear correlations (r=-0.884 to -0.987) were observed between T<inf>c</inf> and TST, NREM sleep periods, and REM sleep periods, except for T<inf>c</inf> and REM sleep periods where fasting and cold conditions were combined. The correlations between sleep and T<inf>c</inf> rhythms were well maintained during cold exposure and fasting. However, when cold and fasting were combined, REM sleep and T<inf>c</inf> rhythms were desynchronized.

    Original languageEnglish
    Pages (from-to)69-75
    Number of pages7
    JournalPhysiology and Behavior
    Volume149
    DOIs
    Publication statusPublished - 2015 Oct 1

    Fingerprint

    Body Temperature
    Fasting
    Sleep
    REM Sleep
    Cold
    Temperature
    Mouse
    Rhythm
    Light
    Inbred ICR Mouse
    Telemetry
    Eye Movements
    Photoperiod
    Electromyography

    Keywords

    • Circadian rhythm
    • Cold exposure
    • Core temperature
    • Feeding condition
    • Sleep-wake rhythm

    ASJC Scopus subject areas

    • Behavioral Neuroscience
    • Experimental and Cognitive Psychology
    • Philosophy

    Cite this

    Cold exposure and/or fasting modulate the relationship between sleep and body temperature rhythms in mice. / Sato, Nobuo; Marui, Shuri; Ozaki, Makoto; Nagashima, Kei.

    In: Physiology and Behavior, Vol. 149, 01.10.2015, p. 69-75.

    Research output: Contribution to journalArticle

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