Collagen-like cell-penetrating peptides

Chisato M. Yamazaki, Ikuhiko Nakase, Hiroyuki Endo, Saya Kishimoto, Yoshihiro Mashiyama, Ryo Masuda, Shiroh Futaki, Takaki Koide

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Arginine-rich heterotrimeric collagen-like peptides were prepared, and their cellular uptake efficiency was evaluated. The spatial arrangement of the Arg residues (blue in picture) on the triple-helix surface significantly affected the efficacy of the cellular uptake. The collagen-like triple-helical conformation provides these cell-penetrating peptides with a high resistance to proteases. O=L-4-hydroxyproline.

Original languageEnglish
Pages (from-to)5497-5500
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number21
DOIs
Publication statusPublished - 2013 May 17

Keywords

  • cell-penetrating peptides
  • cellular uptake
  • collagen
  • peptides
  • protein transduction

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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  • Cite this

    Yamazaki, C. M., Nakase, I., Endo, H., Kishimoto, S., Mashiyama, Y., Masuda, R., Futaki, S., & Koide, T. (2013). Collagen-like cell-penetrating peptides. Angewandte Chemie - International Edition, 52(21), 5497-5500. https://doi.org/10.1002/anie.201301266