Collagen-like cell-penetrating peptides

Chisato M. Yamazaki, Ikuhiko Nakase, Hiroyuki Endo, Saya Kishimoto, Yoshihiro Mashiyama, Ryo Masuda, Shiroh Futaki, Takaki Koide

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Abstract

    Arginine-rich heterotrimeric collagen-like peptides were prepared, and their cellular uptake efficiency was evaluated. The spatial arrangement of the Arg residues (blue in picture) on the triple-helix surface significantly affected the efficacy of the cellular uptake. The collagen-like triple-helical conformation provides these cell-penetrating peptides with a high resistance to proteases. O=L-4-hydroxyproline.

    Original languageEnglish
    Pages (from-to)5497-5500
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Volume52
    Issue number21
    DOIs
    Publication statusPublished - 2013 May 17

    Fingerprint

    Cell-Penetrating Peptides
    Collagen
    Peptides
    Hydroxyproline
    Arginine
    Conformations
    Peptide Hydrolases

    Keywords

    • cell-penetrating peptides
    • cellular uptake
    • collagen
    • peptides
    • protein transduction

    ASJC Scopus subject areas

    • Chemistry(all)
    • Catalysis

    Cite this

    Yamazaki, C. M., Nakase, I., Endo, H., Kishimoto, S., Mashiyama, Y., Masuda, R., ... Koide, T. (2013). Collagen-like cell-penetrating peptides. Angewandte Chemie - International Edition, 52(21), 5497-5500. https://doi.org/10.1002/anie.201301266

    Collagen-like cell-penetrating peptides. / Yamazaki, Chisato M.; Nakase, Ikuhiko; Endo, Hiroyuki; Kishimoto, Saya; Mashiyama, Yoshihiro; Masuda, Ryo; Futaki, Shiroh; Koide, Takaki.

    In: Angewandte Chemie - International Edition, Vol. 52, No. 21, 17.05.2013, p. 5497-5500.

    Research output: Contribution to journalArticle

    Yamazaki, CM, Nakase, I, Endo, H, Kishimoto, S, Mashiyama, Y, Masuda, R, Futaki, S & Koide, T 2013, 'Collagen-like cell-penetrating peptides', Angewandte Chemie - International Edition, vol. 52, no. 21, pp. 5497-5500. https://doi.org/10.1002/anie.201301266
    Yamazaki CM, Nakase I, Endo H, Kishimoto S, Mashiyama Y, Masuda R et al. Collagen-like cell-penetrating peptides. Angewandte Chemie - International Edition. 2013 May 17;52(21):5497-5500. https://doi.org/10.1002/anie.201301266
    Yamazaki, Chisato M. ; Nakase, Ikuhiko ; Endo, Hiroyuki ; Kishimoto, Saya ; Mashiyama, Yoshihiro ; Masuda, Ryo ; Futaki, Shiroh ; Koide, Takaki. / Collagen-like cell-penetrating peptides. In: Angewandte Chemie - International Edition. 2013 ; Vol. 52, No. 21. pp. 5497-5500.
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