Collagen-like triple helical peptides

Applications in drug development and regenerative medicine

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Collagen family proteins are the predominant components of extracellular matrices existing in all multicellular animals. They provide mechanical strength to tissues, and maintain structural integrity of organs. Also, collagens regulate various biological events, including cell attachment, migration, tissue regeneration and animal development. The specific functions of collagens are generally elicited by interactions of collagen-binding molecules (membrane receptors, soluble factors and other matrix components) with certain amino acid sequences displayed on the collagen triple helices. To date, numbers of functional sequences have been identified from the triple helical domains. Collagen is also acknowledged as one of useful biomaterials in regenerative medicine and tissue engineering. In this review, I summarize challenges made for the development of safer and highly-functional collagen surrogates by means of self-assembly of synthetic collagen-like peptides. I also describe other possible applications of collagen-like peptides in drug delivery focusing on the particular biophysical properties of the triple helical structure.

    Original languageEnglish
    Pages (from-to)387-392
    Number of pages6
    JournalYakugaku Zasshi
    Volume133
    Issue number3
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Regenerative Medicine
    Collagen
    Peptides
    Pharmaceutical Preparations
    Biocompatible Materials
    Tissue Engineering
    Cell Movement
    Extracellular Matrix
    Regeneration
    Amino Acid Sequence
    Membranes

    Keywords

    • Biomaterial
    • Collagen
    • Drug delivery
    • Peptide
    • Self-assembly
    • Triple helix

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmaceutical Science

    Cite this

    Collagen-like triple helical peptides : Applications in drug development and regenerative medicine. / Koide, Takaki.

    In: Yakugaku Zasshi, Vol. 133, No. 3, 2013, p. 387-392.

    Research output: Contribution to journalArticle

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