Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model

T. Narisawa, Y. Fukaura, Kazunaga Yazawa, C. Ishikawa, Y. Isoda, Y. Nishizawa

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Background. Epidemiologic and experimental studies suggest that dietary fish oil and vegetable oil high in ω-3 polyunsaturated fatty acids (PUFAs) suppress the risk of colon cancer. The optimal amount to prevent colon carcinogenesis with perilla oil high in ω-3 PUFA α-linolenic acid in a 12% medium-fat diet was investigated in female F344 rats. For comparison, safflower oil high in ω-6 PUFA linoleic acid was used. Methods. Thirty or 25 rats at 7 weeks of age in each group received an intrarectal dose of 2 mg N- methyl-N-nitrosourea 3 times weekly in weeks 1 and 2 and were fed the diets with various levels of perilla oil and safflower oil throughout the experiment. Results. The incidence of colon cancer at the termination of the experiment at week 35 was 40%, 48%, and 32% in the rats fed the diets with 3% perilla oil plus 9% safflower oil, 6% perilla oil plus 6% safflower oil, and 12% perilla oil plus 0% safflower oil, respectively, whereas it was 67% in the rats fed the control diet with 0% perilla oil plus 12% safflower oil. The amount of diet consumed and the body weight gain were identical in all of the dietary groups. The ratios of ω-3 PUFA to ω-6 PUFA in the serum and the colonic mucosa at week 35 were increased in parallel to the increased intake of perilla oil. Conclusions. The results suggest that a relatively small fraction of perilla oil, 25% of total dietary fat, may provide an appreciable beneficial effect in lowering the risk of colon cancer.

Original languageEnglish
Pages (from-to)2069-2075
Number of pages7
JournalCancer
Volume73
Issue number8
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Unsaturated Dietary Fats
alpha-Linolenic Acid
Safflower Oil
Colonic Neoplasms
Animal Models
Unsaturated Fatty Acids
Diet
Methylnitrosourea
Plant Oils
perilla seed oil
Fish Oils
Dietary Fats
Inbred F344 Rats
Linoleic Acid
Weight Gain
Epidemiologic Studies
Colon
Carcinogenesis
Mucous Membrane
Fats

Keywords

  • α- linolenic acid
  • ω-3 fatty acid
  • cancer prevention
  • colon cancer
  • colon carcinogenesis
  • perilla oil

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Narisawa, T., Fukaura, Y., Yazawa, K., Ishikawa, C., Isoda, Y., & Nishizawa, Y. (1994). Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. Cancer, 73(8), 2069-2075.

Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. / Narisawa, T.; Fukaura, Y.; Yazawa, Kazunaga; Ishikawa, C.; Isoda, Y.; Nishizawa, Y.

In: Cancer, Vol. 73, No. 8, 1994, p. 2069-2075.

Research output: Contribution to journalArticle

Narisawa, T, Fukaura, Y, Yazawa, K, Ishikawa, C, Isoda, Y & Nishizawa, Y 1994, 'Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model', Cancer, vol. 73, no. 8, pp. 2069-2075.
Narisawa T, Fukaura Y, Yazawa K, Ishikawa C, Isoda Y, Nishizawa Y. Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. Cancer. 1994;73(8):2069-2075.
Narisawa, T. ; Fukaura, Y. ; Yazawa, Kazunaga ; Ishikawa, C. ; Isoda, Y. ; Nishizawa, Y. / Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. In: Cancer. 1994 ; Vol. 73, No. 8. pp. 2069-2075.
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AU - Isoda, Y.

AU - Nishizawa, Y.

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