Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery

Hongen Liao; Koji Shimaya; Kaimeng Wang; Takashi Maruyama; Masafumi Noguchi; Yoshihiro Muragaki; Etsuko Kobayashi; Hiroshi Iseki; Ichiro Sakuma

doi:10.1007/978-3-540-85990-1_45

Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery

Hongen Liao, Koji Shimaya, Kaimeng Wang, Takashi Maruyama, Masafumi Noguchi, Yoshihiro Muragaki, Etsuko Kobayashi, Hiroshi Iseki, Ichiro Sakuma

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

18 Citations (Scopus)

Abstract

A combination of 5-aminolevulinic acid (5-ALA)-induced fluorescence and three-dimensional (3-D) magnetic resonance imaging (MRI) of a brain tumor has been incorporated into a robotic laser ablation neurosurgery system. 5-ALA is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent protoporphyrins IX (PpIX) in malignant glioma. The PpIX tends to accumulate in pathological lesions, and emits red fluorescence when excited by blue light. This fluorescence is illuminated with laser excitation, enables intra-operative identification of the position of a tumor and provides guidance for resection with laser photocoagulation. The information provided by the MRI is enhanced by the 5-ALA fluorescence data, and this enhanced information is integrated into a robotic laser ablation system. The accuracy of the fluorescent measurement of the tumor is improved using high-precision spectral analysis. The fluorescence assists in the detection of malignant brain tumors intraoperatively and improves their removal rate.

Original language	English
Title of host publication	Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings
Publisher	Springer Verlag
Pages	373-380
Number of pages	8
Edition	PART 2
ISBN (Print)	3540859896, 9783540859895
DOIs	https://doi.org/10.1007/978-3-540-85990-1_45
Publication status	Published - 2008
Event	11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008 - New York, NY, United States Duration: 2008 Sep 6 → 2008 Sep 10

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Number	PART 2
Volume	5242 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008
Country	United States
City	New York, NY
Period	08/9/6 → 08/9/10

ASJC Scopus subject areas

Theoretical Computer Science
Computer Science(all)

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10.1007/978-3-540-85990-1_45

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Liao, H., Shimaya, K., Wang, K., Maruyama, T., Noguchi, M., Muragaki, Y., Kobayashi, E., Iseki, H., & Sakuma, I. (2008). Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. In Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings (PART 2 ed., pp. 373-380). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5242 LNCS, No. PART 2). Springer Verlag. https://doi.org/10.1007/978-3-540-85990-1_45

Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. / Liao, Hongen; Shimaya, Koji; Wang, Kaimeng; Maruyama, Takashi; Noguchi, Masafumi; Muragaki, Yoshihiro; Kobayashi, Etsuko; Iseki, Hiroshi; Sakuma, Ichiro.

Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings. PART 2. ed. Springer Verlag, 2008. p. 373-380 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5242 LNCS, No. PART 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Liao, H, Shimaya, K, Wang, K, Maruyama, T, Noguchi, M, Muragaki, Y, Kobayashi, E, Iseki, H & Sakuma, I 2008, Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. in Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings. PART 2 edn, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), no. PART 2, vol. 5242 LNCS, Springer Verlag, pp. 373-380, 11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008, New York, NY, United States, 08/9/6. https://doi.org/10.1007/978-3-540-85990-1_45

Liao H, Shimaya K, Wang K, Maruyama T, Noguchi M, Muragaki Y et al. Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. In Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings. PART 2 ed. Springer Verlag. 2008. p. 373-380. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 2). https://doi.org/10.1007/978-3-540-85990-1_45

Liao, Hongen ; Shimaya, Koji ; Wang, Kaimeng ; Maruyama, Takashi ; Noguchi, Masafumi ; Muragaki, Yoshihiro ; Kobayashi, Etsuko ; Iseki, Hiroshi ; Sakuma, Ichiro. / Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings. PART 2. ed. Springer Verlag, 2008. pp. 373-380 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 2).

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abstract = "A combination of 5-aminolevulinic acid (5-ALA)-induced fluorescence and three-dimensional (3-D) magnetic resonance imaging (MRI) of a brain tumor has been incorporated into a robotic laser ablation neurosurgery system. 5-ALA is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent protoporphyrins IX (PpIX) in malignant glioma. The PpIX tends to accumulate in pathological lesions, and emits red fluorescence when excited by blue light. This fluorescence is illuminated with laser excitation, enables intra-operative identification of the position of a tumor and provides guidance for resection with laser photocoagulation. The information provided by the MRI is enhanced by the 5-ALA fluorescence data, and this enhanced information is integrated into a robotic laser ablation system. The accuracy of the fluorescent measurement of the tumor is improved using high-precision spectral analysis. The fluorescence assists in the detection of malignant brain tumors intraoperatively and improves their removal rate.",

author = "Hongen Liao and Koji Shimaya and Kaimeng Wang and Takashi Maruyama and Masafumi Noguchi and Yoshihiro Muragaki and Etsuko Kobayashi and Hiroshi Iseki and Ichiro Sakuma",

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AU - Noguchi, Masafumi

AU - Muragaki, Yoshihiro

AU - Kobayashi, Etsuko

AU - Iseki, Hiroshi

AU - Sakuma, Ichiro

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AB - A combination of 5-aminolevulinic acid (5-ALA)-induced fluorescence and three-dimensional (3-D) magnetic resonance imaging (MRI) of a brain tumor has been incorporated into a robotic laser ablation neurosurgery system. 5-ALA is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent protoporphyrins IX (PpIX) in malignant glioma. The PpIX tends to accumulate in pathological lesions, and emits red fluorescence when excited by blue light. This fluorescence is illuminated with laser excitation, enables intra-operative identification of the position of a tumor and provides guidance for resection with laser photocoagulation. The information provided by the MRI is enhanced by the 5-ALA fluorescence data, and this enhanced information is integrated into a robotic laser ablation system. The accuracy of the fluorescent measurement of the tumor is improved using high-precision spectral analysis. The fluorescence assists in the detection of malignant brain tumors intraoperatively and improves their removal rate.

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Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery

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