Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery

Hongen Liao, Koji Shimaya, Kaimeng Wang, Takashi Maruyama, Masafumi Noguchi, Yoshihiro Muragaki, Etsuko Kobayashi, Hiroshi Iseki, Ichiro Sakuma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

18 Citations (Scopus)

Abstract

A combination of 5-aminolevulinic acid (5-ALA)-induced fluorescence and three-dimensional (3-D) magnetic resonance imaging (MRI) of a brain tumor has been incorporated into a robotic laser ablation neurosurgery system. 5-ALA is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent protoporphyrins IX (PpIX) in malignant glioma. The PpIX tends to accumulate in pathological lesions, and emits red fluorescence when excited by blue light. This fluorescence is illuminated with laser excitation, enables intra-operative identification of the position of a tumor and provides guidance for resection with laser photocoagulation. The information provided by the MRI is enhanced by the 5-ALA fluorescence data, and this enhanced information is integrated into a robotic laser ablation system. The accuracy of the fluorescent measurement of the tumor is improved using high-precision spectral analysis. The fluorescence assists in the detection of malignant brain tumors intraoperatively and improves their removal rate.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages373-380
Number of pages8
Volume5242 LNCS
EditionPART 2
DOIs
Publication statusPublished - 2008
Externally publishedYes
Event11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008 - New York, NY
Duration: 2008 Sep 62008 Sep 10

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 2
Volume5242 LNCS
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008
CityNew York, NY
Period08/9/608/9/10

Fingerprint

Neurosurgery
Laser Ablation
Laser ablation
Fluorescence
3D
Guidance
Robotics
Imaging
Tumors
Imaging techniques
Acids
Brain Tumor
Magnetic Resonance Imaging
Magnetic resonance
Tumor
Brain
Laser
Blue Light
3D Imaging
Laser excitation

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

Cite this

Liao, H., Shimaya, K., Wang, K., Maruyama, T., Noguchi, M., Muragaki, Y., ... Sakuma, I. (2008). Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (PART 2 ed., Vol. 5242 LNCS, pp. 373-380). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5242 LNCS, No. PART 2). https://doi.org/10.1007/978-3-540-85990-1-45

Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. / Liao, Hongen; Shimaya, Koji; Wang, Kaimeng; Maruyama, Takashi; Noguchi, Masafumi; Muragaki, Yoshihiro; Kobayashi, Etsuko; Iseki, Hiroshi; Sakuma, Ichiro.

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 5242 LNCS PART 2. ed. 2008. p. 373-380 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5242 LNCS, No. PART 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Liao, H, Shimaya, K, Wang, K, Maruyama, T, Noguchi, M, Muragaki, Y, Kobayashi, E, Iseki, H & Sakuma, I 2008, Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). PART 2 edn, vol. 5242 LNCS, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), no. PART 2, vol. 5242 LNCS, pp. 373-380, 11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008, New York, NY, 08/9/6. https://doi.org/10.1007/978-3-540-85990-1-45
Liao H, Shimaya K, Wang K, Maruyama T, Noguchi M, Muragaki Y et al. Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). PART 2 ed. Vol. 5242 LNCS. 2008. p. 373-380. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 2). https://doi.org/10.1007/978-3-540-85990-1-45
Liao, Hongen ; Shimaya, Koji ; Wang, Kaimeng ; Maruyama, Takashi ; Noguchi, Masafumi ; Muragaki, Yoshihiro ; Kobayashi, Etsuko ; Iseki, Hiroshi ; Sakuma, Ichiro. / Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 5242 LNCS PART 2. ed. 2008. pp. 373-380 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 2).
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