Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery.

Hongen Liao, Koji Shimaya, Kaimeng Wang, Takashi Maruyama, Masafumi Noguchi, Yoshihiro Muragaki, Etsuko Kobayashi, Hiroshi Iseki, Ichiro Sakuma

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A combination of 5-aminolevulinic acid (5-ALA)-induced fluorescence and three-dimensional (3-D) magnetic resonance imaging (MRI) of a brain tumor has been incorporated into a robotic laser ablation neurosurgery system. 5-ALA is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent protoporphyrins IX (PpIX) in malignant glioma. The PpIX tends to accumulate in pathological lesions, and emits red fluorescence when excited by blue light. This fluorescence is illuminated with laser excitation, enables intra-operative identification of the position of a tumor and provides guidance for resection with laser photocoagulation. The information provided by the MRI is enhanced by the 5-ALA fluorescence data, and this enhanced information is integrated into a robotic laser ablation system. The accuracy of the fluorescent measurement of the tumor is improved using high-precision spectral analysis. The fluorescence assists in the detection of malignant brain tumors intraoperatively and improves their removal rate.

Original languageEnglish
Title of host publicationMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Pages373-380
Number of pages8
Volume11
EditionPt 2
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Aminolevulinic Acid
Three-Dimensional Imaging
Neurosurgery
Robotics
Laser Therapy
Fluorescence
Brain Neoplasms
Lasers
Magnetic Resonance Imaging
Light Coagulation
Prodrugs
Glioma
Neoplasms
Light

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Liao, H., Shimaya, K., Wang, K., Maruyama, T., Noguchi, M., Muragaki, Y., ... Sakuma, I. (2008). Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention (Pt 2 ed., Vol. 11, pp. 373-380)

Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. / Liao, Hongen; Shimaya, Koji; Wang, Kaimeng; Maruyama, Takashi; Noguchi, Masafumi; Muragaki, Yoshihiro; Kobayashi, Etsuko; Iseki, Hiroshi; Sakuma, Ichiro.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 11 Pt 2. ed. 2008. p. 373-380.

Research output: Chapter in Book/Report/Conference proceedingChapter

Liao, H, Shimaya, K, Wang, K, Maruyama, T, Noguchi, M, Muragaki, Y, Kobayashi, E, Iseki, H & Sakuma, I 2008, Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 2 edn, vol. 11, pp. 373-380.
Liao H, Shimaya K, Wang K, Maruyama T, Noguchi M, Muragaki Y et al. Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 2 ed. Vol. 11. 2008. p. 373-380
Liao, Hongen ; Shimaya, Koji ; Wang, Kaimeng ; Maruyama, Takashi ; Noguchi, Masafumi ; Muragaki, Yoshihiro ; Kobayashi, Etsuko ; Iseki, Hiroshi ; Sakuma, Ichiro. / Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 11 Pt 2. ed. 2008. pp. 373-380
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AU - Maruyama, Takashi

AU - Noguchi, Masafumi

AU - Muragaki, Yoshihiro

AU - Kobayashi, Etsuko

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AU - Sakuma, Ichiro

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