Combined association of cardiorespiratory fitness and family history of hypertension on the incidence of hypertension

a long-term cohort study of Japanese males

Yuko Gando, Susumu Sawada, Ryoko Kawakami, Haruki Momma, Kazunori Shimada, Yasushi Fukunaka, Takashi Okamoto, Koji Tsukamoto, Motohiko Miyachi, I. Min Lee, Steven N. Blair

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Family history of hypertension (FH) is a nonmodifiable risk factor for hypertension. However, cardiorespiratory fitness (CRF) is a modifiable risk factor and might be important for preventing hypertension in both people with and without FH. The purpose of this study was to investigate the combined association of CRF and FH on the incidence of hypertension in normotensive male Japanese workers. A total of 6890 workers were included in this study. CRF was determined using a submaximal exercise test. A self-reported questionnaire was used to determine FH. Six groups were established, combining the two groups with and without FH (Yes, No) and the three CRF groups (Low, Moderate, High). The incidence of hypertension, defined as systolic blood pressure of ≥140 mmHg or diastolic blood pressure of ≥90 mmHg, or self-reported physician-diagnosed hypertension was evaluated. During the observation period of 101,212 man-years (median 17 years, minimum 1 year, maximum 23 years), 2210 workers developed hypertension. There were 3860 participants who had FH (56%). Compared with the Yes-Low CRF group, the HRs (95% CI) for hypertension were 66% lower in the No-High CRF group (0.34 [0.28–0.40]), 47% lower in the No-Low CRF group (0.53 [0.46–0.61]), and 24% lower in the Yes-High CRF group (0.76 [0.67–0.86]). FH and CRF did not show a significant interaction (p for interaction = 0.181). The combination of FH and CRF showed a clear association with the risk of incident hypertension, and moderate to high levels of CRF might be equally beneficial for preventing hypertension for both people with and without FH.

Original languageEnglish
JournalHypertension Research
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Fingerprint

Cohort Studies
Hypertension
Incidence
Blood Pressure
Cardiorespiratory Fitness
Exercise Test
Observation

Keywords

  • Blood pressure
  • Family history
  • Fitness
  • Hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Combined association of cardiorespiratory fitness and family history of hypertension on the incidence of hypertension : a long-term cohort study of Japanese males. / Gando, Yuko; Sawada, Susumu; Kawakami, Ryoko; Momma, Haruki; Shimada, Kazunori; Fukunaka, Yasushi; Okamoto, Takashi; Tsukamoto, Koji; Miyachi, Motohiko; Lee, I. Min; Blair, Steven N.

In: Hypertension Research, 01.01.2018.

Research output: Contribution to journalArticle

Gando, Yuko ; Sawada, Susumu ; Kawakami, Ryoko ; Momma, Haruki ; Shimada, Kazunori ; Fukunaka, Yasushi ; Okamoto, Takashi ; Tsukamoto, Koji ; Miyachi, Motohiko ; Lee, I. Min ; Blair, Steven N. / Combined association of cardiorespiratory fitness and family history of hypertension on the incidence of hypertension : a long-term cohort study of Japanese males. In: Hypertension Research. 2018.
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abstract = "Family history of hypertension (FH) is a nonmodifiable risk factor for hypertension. However, cardiorespiratory fitness (CRF) is a modifiable risk factor and might be important for preventing hypertension in both people with and without FH. The purpose of this study was to investigate the combined association of CRF and FH on the incidence of hypertension in normotensive male Japanese workers. A total of 6890 workers were included in this study. CRF was determined using a submaximal exercise test. A self-reported questionnaire was used to determine FH. Six groups were established, combining the two groups with and without FH (Yes, No) and the three CRF groups (Low, Moderate, High). The incidence of hypertension, defined as systolic blood pressure of ≥140 mmHg or diastolic blood pressure of ≥90 mmHg, or self-reported physician-diagnosed hypertension was evaluated. During the observation period of 101,212 man-years (median 17 years, minimum 1 year, maximum 23 years), 2210 workers developed hypertension. There were 3860 participants who had FH (56{\%}). Compared with the Yes-Low CRF group, the HRs (95{\%} CI) for hypertension were 66{\%} lower in the No-High CRF group (0.34 [0.28–0.40]), 47{\%} lower in the No-Low CRF group (0.53 [0.46–0.61]), and 24{\%} lower in the Yes-High CRF group (0.76 [0.67–0.86]). FH and CRF did not show a significant interaction (p for interaction = 0.181). The combination of FH and CRF showed a clear association with the risk of incident hypertension, and moderate to high levels of CRF might be equally beneficial for preventing hypertension for both people with and without FH.",
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