TY - JOUR
T1 - Community effect of cardiomyocytes in beating rhythms is determined by stable cells
AU - Hayashi, Tatsuya
AU - Tokihiro, Tetsuji
AU - Kurihara, Hiroki
AU - Yasuda, Kenji
N1 - Funding Information:
Part of this work was supported by Core Research for Evolutional Science and Technology (CREST) of the Japan Science and Technology Agency (JST), Japan, and by Platform for Dynamic Approaches to Living System from the Ministry of Education, Culture, Sports, Science and Technology, Japan. We thank Ellen Knapp, PhD.
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/1
Y1 - 2017/12/1
N2 - The community effect of cardiomyocytes was investigated in silico by the change in number and features of cells, as well as configurations of networks. The theoretical model was based on experimental data and accurately reproduced recently published experimental results regarding coupled cultured cardiomyocytes. We showed that the synchronised beating of two coupled cells was tuned not to the cell with a faster beating rate, but to the cell with a more stable rhythm. In a network of cardiomyocytes, a cell with low fluctuation, but not a hight frequency, became a pacemaker and stabilised the beating rhythm. Fluctuation in beating rapidly decreased with an increase in the number of cells (N), almost irrespective of the configuration of the network, and a cell comes to have natural and stable beating rhythms, even for N of approximately 10. The universality of this community effect lies in the fluctuation-dissipation theorem in statistical mechanics.
AB - The community effect of cardiomyocytes was investigated in silico by the change in number and features of cells, as well as configurations of networks. The theoretical model was based on experimental data and accurately reproduced recently published experimental results regarding coupled cultured cardiomyocytes. We showed that the synchronised beating of two coupled cells was tuned not to the cell with a faster beating rate, but to the cell with a more stable rhythm. In a network of cardiomyocytes, a cell with low fluctuation, but not a hight frequency, became a pacemaker and stabilised the beating rhythm. Fluctuation in beating rapidly decreased with an increase in the number of cells (N), almost irrespective of the configuration of the network, and a cell comes to have natural and stable beating rhythms, even for N of approximately 10. The universality of this community effect lies in the fluctuation-dissipation theorem in statistical mechanics.
UR - http://www.scopus.com/inward/record.url?scp=85034105008&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034105008&partnerID=8YFLogxK
U2 - 10.1038/s41598-017-15727-5
DO - 10.1038/s41598-017-15727-5
M3 - Article
C2 - 29133848
AN - SCOPUS:85034105008
SN - 2045-2322
VL - 7
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 15450
ER -