Comparative study of two ribozymes and DNA-enzyme against the same RNA target.

O. Inui, Yo Kikuchi, N. Dohi, N. Okada, H. Okada, T. Tanaka

Research output: Contribution to journalArticle

Abstract

Two ribozymes, hammerhead ribozyme and hairpin ribozyme, and a DNA-enzyme were designed to cleave a same RNA target, the same site of the rat complement regulatory factor 512 antigen mRNA. The kinetic properties of these RNA-cleaving enzymes were measured and compared under the same conditions, using multiple turnover kinetics and competition kinetics. The catalytic efficiencies of these enzymes, and also the order of these enzymes will be discussed.

Original languageEnglish
Pages (from-to)217-218
Number of pages2
JournalNucleic acids symposium series
Issue number42
Publication statusPublished - 1999
Externally publishedYes

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    Inui, O., Kikuchi, Y., Dohi, N., Okada, N., Okada, H., & Tanaka, T. (1999). Comparative study of two ribozymes and DNA-enzyme against the same RNA target. Nucleic acids symposium series, (42), 217-218.