Comparative study of two ribozymes and DNA-enzyme against the same RNA target.

O. Inui; Yo Kikuchi; N. Dohi; N. Okada; H. Okada; T. Tanaka

Comparative study of two ribozymes and DNA-enzyme against the same RNA target.

O. Inui, Yo Kikuchi, N. Dohi, N. Okada, H. Okada, T. Tanaka

Research output: Contribution to journal › Article › peer-review

Abstract

Two ribozymes, hammerhead ribozyme and hairpin ribozyme, and a DNA-enzyme were designed to cleave a same RNA target, the same site of the rat complement regulatory factor 512 antigen mRNA. The kinetic properties of these RNA-cleaving enzymes were measured and compared under the same conditions, using multiple turnover kinetics and competition kinetics. The catalytic efficiencies of these enzymes, and also the order of these enzymes will be discussed.

Original language	English
Pages (from-to)	217-218
Number of pages	2
Journal	Nucleic acids symposium series
Issue number	42
Publication status	Published - 1999
Externally published	Yes

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abstract = "Two ribozymes, hammerhead ribozyme and hairpin ribozyme, and a DNA-enzyme were designed to cleave a same RNA target, the same site of the rat complement regulatory factor 512 antigen mRNA. The kinetic properties of these RNA-cleaving enzymes were measured and compared under the same conditions, using multiple turnover kinetics and competition kinetics. The catalytic efficiencies of these enzymes, and also the order of these enzymes will be discussed.",

author = "O. Inui and Yo Kikuchi and N. Dohi and N. Okada and H. Okada and T. Tanaka",

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AU - Okada, H.

AU - Tanaka, T.

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AB - Two ribozymes, hammerhead ribozyme and hairpin ribozyme, and a DNA-enzyme were designed to cleave a same RNA target, the same site of the rat complement regulatory factor 512 antigen mRNA. The kinetic properties of these RNA-cleaving enzymes were measured and compared under the same conditions, using multiple turnover kinetics and competition kinetics. The catalytic efficiencies of these enzymes, and also the order of these enzymes will be discussed.

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