Comparison between clinical significance of height-adjusted and weight-adjusted appendicular skeletal muscle mass

Taishi Furushima, Motohiko Miyachi, Motoyuki Iemitsu, Haruka Murakami, Hiroshi Kawano, Yuko Gando, Ryoko Kawakami, Kiyoshi Sanada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND: This study aimed to compare relationships between height- or weight-adjusted appendicular skeletal muscle mass (ASM/Ht2 or ASM/Wt) and risk factors for cardiometabolic diseases or osteoporosis in Japanese men and women.

METHODS: Subjects were healthy Japanese men (n = 583) and women (n = 1218). The study population included a young group (310 men and 357 women; age, 18-40 years) and a middle-aged and elderly group (273 men and 861 women; age, ≥41 years). ASM was measured by dual-energy X-ray absorptiometry. The reference values for class 1 and 2 sarcopenia in each sex were defined as values one and two standard deviations below the sex-specific means of the young group, respectively.

RESULTS: The reference values for class 1 and 2 sarcopenia defined by ASM/Ht2 were 7.77 and 6.89 kg/m2 in men and 6.06 and 5.31 kg/m2 in women, respectively. The reference values for ASM/Wt were 35.0 and 32.0% in men and 29.6 and 26.4% in women, respectively. In both men and women, ASM/Wt was negatively correlated with higher triglycerides (TG) and positively correlated with serum high-density lipoprotein cholesterol (HDL-C), but these associations were not found in height-adjusted ASM. In women, TG, systolic blood pressure, and diastolic blood pressure in sarcopenia defined by ASM/Wt were significantly higher than those in normal subjects, but these associations were not found in sarcopenia defined by ASM/Ht2. Whole-body and regional bone mineral density in sarcopenia defined by ASM/Ht2 were significantly lower than those in normal subjects, but these associations were not found in sarcopenia defined by ASM/Wt.

CONCLUSIONS: Weight-adjusted definition was able to identify cardiometabolic risk factors such as TG and HDL-C while height-adjusted definition could identify factors for osteoporosis.

Original languageEnglish
Number of pages1
JournalJournal of Physiological Anthropology
Volume36
Issue number1
DOIs
Publication statusPublished - 2017 Feb 13

Fingerprint

Sarcopenia
Muscle
Lipoproteins
Skeletal Muscle
Cholesterol
Blood pressure
Weights and Measures
Blood Pressure
bone disease
Reference Values
Triglycerides
Bone
Minerals
HDL Cholesterol
Osteoporosis
X rays
Paraphilic Disorders
Group
Photon Absorptiometry
Bone Density

Keywords

  • Body height
  • Body weight
  • Cardiometabolic diseases
  • Definition
  • Osteoporosis
  • Sarcopenia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Comparison between clinical significance of height-adjusted and weight-adjusted appendicular skeletal muscle mass. / Furushima, Taishi; Miyachi, Motohiko; Iemitsu, Motoyuki; Murakami, Haruka; Kawano, Hiroshi; Gando, Yuko; Kawakami, Ryoko; Sanada, Kiyoshi.

In: Journal of Physiological Anthropology, Vol. 36, No. 1, 13.02.2017.

Research output: Contribution to journalArticle

Furushima, Taishi ; Miyachi, Motohiko ; Iemitsu, Motoyuki ; Murakami, Haruka ; Kawano, Hiroshi ; Gando, Yuko ; Kawakami, Ryoko ; Sanada, Kiyoshi. / Comparison between clinical significance of height-adjusted and weight-adjusted appendicular skeletal muscle mass. In: Journal of Physiological Anthropology. 2017 ; Vol. 36, No. 1.
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T1 - Comparison between clinical significance of height-adjusted and weight-adjusted appendicular skeletal muscle mass

AU - Furushima, Taishi

AU - Miyachi, Motohiko

AU - Iemitsu, Motoyuki

AU - Murakami, Haruka

AU - Kawano, Hiroshi

AU - Gando, Yuko

AU - Kawakami, Ryoko

AU - Sanada, Kiyoshi

PY - 2017/2/13

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N2 - BACKGROUND: This study aimed to compare relationships between height- or weight-adjusted appendicular skeletal muscle mass (ASM/Ht2 or ASM/Wt) and risk factors for cardiometabolic diseases or osteoporosis in Japanese men and women.METHODS: Subjects were healthy Japanese men (n = 583) and women (n = 1218). The study population included a young group (310 men and 357 women; age, 18-40 years) and a middle-aged and elderly group (273 men and 861 women; age, ≥41 years). ASM was measured by dual-energy X-ray absorptiometry. The reference values for class 1 and 2 sarcopenia in each sex were defined as values one and two standard deviations below the sex-specific means of the young group, respectively.RESULTS: The reference values for class 1 and 2 sarcopenia defined by ASM/Ht2 were 7.77 and 6.89 kg/m2 in men and 6.06 and 5.31 kg/m2 in women, respectively. The reference values for ASM/Wt were 35.0 and 32.0% in men and 29.6 and 26.4% in women, respectively. In both men and women, ASM/Wt was negatively correlated with higher triglycerides (TG) and positively correlated with serum high-density lipoprotein cholesterol (HDL-C), but these associations were not found in height-adjusted ASM. In women, TG, systolic blood pressure, and diastolic blood pressure in sarcopenia defined by ASM/Wt were significantly higher than those in normal subjects, but these associations were not found in sarcopenia defined by ASM/Ht2. Whole-body and regional bone mineral density in sarcopenia defined by ASM/Ht2 were significantly lower than those in normal subjects, but these associations were not found in sarcopenia defined by ASM/Wt.CONCLUSIONS: Weight-adjusted definition was able to identify cardiometabolic risk factors such as TG and HDL-C while height-adjusted definition could identify factors for osteoporosis.

AB - BACKGROUND: This study aimed to compare relationships between height- or weight-adjusted appendicular skeletal muscle mass (ASM/Ht2 or ASM/Wt) and risk factors for cardiometabolic diseases or osteoporosis in Japanese men and women.METHODS: Subjects were healthy Japanese men (n = 583) and women (n = 1218). The study population included a young group (310 men and 357 women; age, 18-40 years) and a middle-aged and elderly group (273 men and 861 women; age, ≥41 years). ASM was measured by dual-energy X-ray absorptiometry. The reference values for class 1 and 2 sarcopenia in each sex were defined as values one and two standard deviations below the sex-specific means of the young group, respectively.RESULTS: The reference values for class 1 and 2 sarcopenia defined by ASM/Ht2 were 7.77 and 6.89 kg/m2 in men and 6.06 and 5.31 kg/m2 in women, respectively. The reference values for ASM/Wt were 35.0 and 32.0% in men and 29.6 and 26.4% in women, respectively. In both men and women, ASM/Wt was negatively correlated with higher triglycerides (TG) and positively correlated with serum high-density lipoprotein cholesterol (HDL-C), but these associations were not found in height-adjusted ASM. In women, TG, systolic blood pressure, and diastolic blood pressure in sarcopenia defined by ASM/Wt were significantly higher than those in normal subjects, but these associations were not found in sarcopenia defined by ASM/Ht2. Whole-body and regional bone mineral density in sarcopenia defined by ASM/Ht2 were significantly lower than those in normal subjects, but these associations were not found in sarcopenia defined by ASM/Wt.CONCLUSIONS: Weight-adjusted definition was able to identify cardiometabolic risk factors such as TG and HDL-C while height-adjusted definition could identify factors for osteoporosis.

KW - Body height

KW - Body weight

KW - Cardiometabolic diseases

KW - Definition

KW - Osteoporosis

KW - Sarcopenia

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