Comparison of the effects of individual symptoms of gastroesophageal reflux disease co-existing functional dyspepsia on patients' daily lives: A prospective, observational study

Tatsuya Nakada*, Kimio Isshi, Nobuyuki Matsuhashi, Katsuhiko Iwakiri, Takeshi Kamiya, Noriaki Manabe, Kazuhide Higuchi, Takashi Joh, Atsushi Oshio, Maiko Ogawa, Atsushi Hokari, Masayuki Saruta, Ken Haruma, Koji Nakada

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Aim: Patients with gastroesophageal reflux disease (GERD) frequently also have functional dyspepsia (FD) symptoms, which impair their quality of life. However, the magnitude and characteristics of the effects of each symptom on daily life have been unclarified. Using multiple regression analysis, we aimed to clarify these questions. Methods: We enrolled 290 patients from 29 institutions across Japan, in this prospective, observational study. Patients responded to three questionnaires (Gastroesophageal Reflux and Dyspepsia Therapeutic Efficacy and Satisfaction Test [GERD-TEST], Hospital Anxiety and Depression Scale [HADS], and 8-item Short-Form Health Survey [SF-8]) before and after 4 weeks of proton pump inhibitor treatment. Pearson correlation and multiple regression analyses were conducted between symptoms such as typical GERD, epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS) of FD, and aspects of daily life, namely, level of satisfaction with the daily life of GERD-TEST, anxiety and depression score of HADS, and physical and mental component summary of SF-8. Results: Pearson correlation analysis showed a significant correlation in all combinations between GERD/FD-EPS/FD-PDS symptoms and the nine aspects of daily life. However, multiple regression analysis results deviated from these results, with the most significant effects seen in the PDS-symptom subscale (SS) on the five aspects of daily life, that is, dissatisfaction with eating, daily life-SS, anxiety, depression, and mental component summary (MCS) whereas the significant effects in GERD-SS on five aspects of daily life, that is, dissatisfaction for eating, anxiety, depression, physical component summary, and MCS, disappeared. Conclusion: Dealing with co-existing FD symptoms without overlooking them may be important in the management of GERD.

Original languageEnglish
Pages (from-to)886-893
Number of pages8
JournalJGH Open
Volume6
Issue number12
DOIs
Publication statusPublished - 2022 Dec

Keywords

  • functional dyspepsia
  • gastroesophageal reflux disease
  • multiple analysis
  • psychiatric disorder
  • quality of life

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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